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      Clinical Interventions in Aging (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on prevention and treatment of diseases in people over 65 years of age. Sign up for email alerts here.

      36,334 Monthly downloads/views I 3.829 Impact Factor I 7.4 CiteScore I 1.83 Source Normalized Impact per Paper (SNIP) I 1.044 Scimago Journal & Country Rank (SJR)

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      Is Open Access

      The Effect of Theracurmin on Cognitive Function in an Older Patient with Chemobrain

      case-report

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          Abstract

          Chemobrain is one of the problems that may arise during or after treatment and there is currently no specific treatment for this condition. Our case was a 76-year-old female patient who presented to our clinic with complaints of forgetfulness that did not affect daily living activities for the last year. Breast cancer was diagnosed in 2013 and she has been receiving anastrozole treatment for 6 years after local mass excision surgery and radiotherapy. After a comprehensive geriatric evaluation, cognitive impairment due to systemic cancer therapy was detected and treatment was started with Theracurmin 90 mg twice a day therapy. After 3-months of Theracurmin therapy, she had no cognitive improvement during the follow-up. This case report demonstrated that Theracurmin treatment may be a new option for chemobrain.

          Most cited references9

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          Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

          Karen J Miller, Natacha D Emerson, Jacqueline Martínez … (2018)
          Article 0 comments Cited 99 times – based on 0 reviews     Review now
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            Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy.

            Xiao-min Wang, Brian Walitt, Leorey Saligan … (2015)
            One consequence of modern cancer therapy is chemotherapy related cognitive dysfunction or "chemobrain", the subjective experience of cognitive deficits at any point during or following chemotherapy. Chemobrain, a well-established clinical syndrome, has become an increasing concern because the number of long-term cancer survivors is growing dramatically. There is strong evidence that correlates changes in peripheral cytokines with the development of chemobrain in commonly used chemotherapeutic drugs for different types of cancer. However, the mechanisms by which these cytokines elicit change in the central nervous system are still unclear. In this review, we hypothesize that the administration of chemotherapy agents initiates a cascade of biological changes, with short-lived alterations in the cytokine milieu inducing persistent epigenetic alterations. These epigenetic changes lead to changes in gene expression, alterations in metabolic activity and neuronal transmission that are responsible for generating the subjective experience of cognition. This speculative but testable hypothesis should help to gain a comprehensive understanding of the mechanism underlying cognitive dysfunction in cancer patients. Such knowledge is critical to identify pharmaceutical targets with the potential to prevent and treat cancer-treatment related cognitive dysfunction and similar disorders.
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              Curcumin targets in inflammation and cancer.

              Atsuko Deguchi (2015)
              Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is commonly used as a spice, food additive or dietary pigment. Accumulating evidence suggests that curcumin has several pharmacologic effects, including anti-inflammatory, anti-oxidant and anti-cancer activities. The molecular mechanisms underlying the targets of curcumin are diverse and involve combinations of multiple signaling pathways, including NF-κB and STAT3 signaling. Thus, curcumin is one of the most promising phytochemicals that target various cancers and inflammation-mediated diseases. Clinical trials have been ongoing or completed for various cancers, including breast, pancreatic and colorectal cancers, and multiple myeloma. In this review, the molecular mechanisms and the issue of bioavailability are mainly discussed.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Clin Interv Aging
                Journal ID (iso-abbrev): Clin Interv Aging
                Journal ID (publisher-id): CIA
                Journal ID (pmc): clinintag
                Title: Clinical Interventions in Aging
                Publisher: Dove
                ISSN (Print): 1176-9092
                ISSN (Electronic): 1178-1998
                Publication date (Electronic): 19 May 2020
                Publication date Collection: 2020
                Volume: 15
                Pages: 691-693
                Affiliations
                [1 ]Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University , Izmir, Turkey
                [2 ]Department of Geriatric Medicine, Bezmialem Vakif University, Faculty of Medicine , Istanbul, Turkey
                Author notes
                Correspondence: Ahmet Turan Isik Unit for Brain Aging and Dementia, Department of Geriatric Medicine, School of Medicine, Dokuz Eylul University , Izmir, TurkeyTel +90 232 412 43 41Fax +90 232 412 43 49 Email atisik@yahoo.com
                Author information
                http://orcid.org/0000-0002-4878-1569
                http://orcid.org/0000-0002-3748-8156
                http://orcid.org/0000-0002-6042-1718
                http://orcid.org/0000-0001-5867-6503
                Article
                Publisher ID: 252229
                DOI: 10.2147/CIA.S252229
                PMC ID: 7245427
                PubMed ID: 32546987
                SO-VID: 21608eb1-0f61-4012-a27c-d1938c38d4f1
                Copyright © © 2020 Erken et al.
                License:

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                Date received : 03 March 2020
                Date accepted : 29 April 2020
                Page count
                Tables: 1, References: 12, Pages: 3
                Categories
                Subject: Case Report

                ScienceOpen disciplines: Health & Social care
                Keywords: chemobrain,theracurmin,elderly,cognitive impairment,cancer
                Data availability:
                ScienceOpen disciplines: Health & Social care
                Keywords: chemobrain, theracurmin, elderly, cognitive impairment, cancer

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