<p class="first" id="d1937239e166">Mulberry leaves are one of the most commonly used
medicinal and herbaceous traditional
Chinese medicines that are currently considered for the treatment of diabetes mellitus
and its complications. The alkaloids, flavonoids, and polysaccharides in mulberry
leaves impart regulatory effects on blood sugar levels. To identify the hypoglycemia-related
active components in mulberry leaves and their targets, the present study conducted
gas chromatography-mass spectrometer (GC/MS), which identified 202 components of mulberry
leaf, of which 22 components may have significant curative effects on diabetes mellitus
and its complications and chronic inflammation. The network-based pharmacological
analysis platform was used to identify target proteins related to diabetes. Finally,
the interaction networks of these target proteins were identified using STRING and
Cytoscape. The results showed that mulberry leaf powder contains tricetin, gallic
acid, chlorogenic acid, and other drug components that can regulate tumor necrosis
factor (TNF), peroxisome proliferator-activated receptor gamma (PPARG), glycogen synthase
kinase-3 beta (GSK3B), insulin receptor substrate 1 (IRS1), interleukin 6 (IL-6) and
other proteins, which are related to the insulin and inflammatory signaling pathways,
glucose metabolism and other related pathways, chronic inflammatory diseases, obesity,
diabetic nephropathy, non-insulin-dependent diabetes mellitus and other diseases.
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