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      Reinventing Molecular Imaging with Total-Body PET, Part II : Clinical Applications

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          Abstract

          Total-body PET scans will initiate a new era for the PET clinic. The benefits of 40-fold effective sensitivity improvement provide new capabilities to image with lower radiation dose, perform delayed imaging, and achieve improved temporal resolution. These technical features are detailed in the first of this 2-part series. In this part, the clinical impacts of the novel features of total-body PET scans are further explored. Applications of total-body PET scans focus on the real-time interrogation of systemic disease manifestations in a variety of practical clinical contexts. Total-body PET scans make clinical systems biology imaging a reality.

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          Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

          Ling Mao, Huijuan Jin, Mengdie Wang … (2020)
          The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. However, to our knowledge, it has not been reported that patients with COVID-19 had any neurologic manifestations.
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            First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*

            Ramsey D. Badawi, Hongcheng Shi, Pengcheng Hu … (2019)
            Within the EXPLORER Consortium, the construction of the world's first total-body PET/CT scanner has recently been completed. The 194-cm axial field of view of the EXPLORER PET/CT scanner is sufficient to cover, for the first time, the entire human adult body in a single acquisition in more than 99% of the population and allows total-body pharmacokinetic studies with frame durations as short as 1 s. The large increase in sensitivity arising from total-body coverage as well as increased solid angle for detection at any point within the body allows whole-body 18F-FDG PET studies to be acquired with unprecedented count density, improving the signal-to-noise ratio of the resulting images. Alternatively, the sensitivity gain can be used to acquire diagnostic PET images with very small amounts of activity in the field of view (25 MBq, 0.7 mCi or less), with very short acquisition times (∼1 min or less) or at later time points after the tracer's administration. We report here on the first human imaging studies on the EXPLORER scanner using a range of different protocols that provide initial evidence in support of these claims. These case studies provide the foundation for future carefully controlled trials to quantitatively evaluate the improvements possible through total-body PET imaging.
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              Complicaciones neurológicas por coronavirus y COVID-19

              Francisco Carod Artal (2020)
              Clinical and experimental studies have shown that the coronavirus family has a certain tropism for the central nervous system. Seven types of coronavirus can infect humans.
              Article 0 comments Cited 185 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): PET Clin
                Journal ID (iso-abbrev): PET Clin
                Title: Pet Clinics
                Publisher: Elsevier Inc.
                ISSN (Print): 1556-8598
                ISSN (Electronic): 1879-9809
                Publication date PMC-release: 1 September 2020
                Publication date (Print): October 2020
                Publication date (Electronic): 1 September 2020
                Volume: 15
                Issue: 4
                Pages: 463-475
                Affiliations
                [a ]Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
                [b ]Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore, MD, USA
                [c ]Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
                Author notes
                [∗ ]Corresponding author. 3400 Spruce Street, Philadelphia, PA 19104.
                Article
                Publisher ID: S1556-8598(20)30051-1
                DOI: 10.1016/j.cpet.2020.06.013
                PMC ID: 7462547
                SO-VID: a0a06305-7563-431c-b157-ed099006bea2
                Copyright © © 2020 Elsevier Inc. All rights reserved.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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                Subject: Article

                Keywords: total-body pet,oncoradiology,oncology,inflammation imaging,vascular imaging
                Data availability:
                Keywords: total-body pet, oncoradiology, oncology, inflammation imaging, vascular imaging

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