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PRDX3 is associated with metastasis and poor survival in uveal melanoma.
Pathma Ramasamy
1
,
2
,
3 ,
Anne-Marie Larkin
2
,
4 ,
Annett Linge
2 ,
Damien Tiernan
5 ,
Fionnuala McAree
5 ,
Noel Horgan
5 ,
Paul Moriarty
5 ,
Stephen Beatty
6 ,
Conor C Murphy
7
,
5 ,
Martin Clynes
2
,
8 ,
Susan Kennedy
9 ,
Paula Meleady
2
Jul 2020
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Abstract
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and 40% develop fatal metastatic disease. Overexpression of thioredoxin-dependent peroxidase reductase (PRDX3) has been implicated in several cancers, including prostate, breast, colorectal and lung cancer. The aim of this study was to compare the immunohistochemical expression of PRDX3 in formalin-fixed, paraffin-embedded (FFPE) primary UM tissues of patients who did and did not develop metastatic disease.