External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial.

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Abstract

Whole breast irradiation delivered once per day over 3-5 weeks after breast conserving surgery reduces local recurrence with good cosmetic results. Accelerated partial breast irradiation (APBI) delivered over 1 week to the tumour bed was developed to provide a more convenient treatment. In this trial, we investigated if external beam APBI was non-inferior to whole breast irradiation.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): December 14 2019

Volume: 394

Issue: 10215

Affiliations

[1 ] Department of Oncology, McMaster University and Juravinski Cancer Centre, Hamilton, ON, Canada. Electronic address: twhelan@hhsc.ca.

[2 ] Department of Oncology, McMaster University and Juravinski Cancer Centre, Hamilton, ON, Canada.

[3 ] Radiation Therapy Program, BC Cancer - Victoria, University of British Columbia, Vancouver, BC, Canada.

[4 ] Department of Radiation Oncology, CHU de Québec - Université Laval, Québec, QC, Canada.

[5 ] Division of Radiation Oncology, University of British Columbia and BC Cancer - Vancouver, BC, Canada.

[6 ] Department of Radiation Oncology, University of Manitoba, Winnipeg, MB, Canada.

[7 ] Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada.

[8 ] Department of Radiation Oncology, CHU de Québec - Université Laval, Québec, QC, Canada; Division of Radiation Oncology, University of British Columbia and BC Cancer - Kelowna, BC, Canada.

[9 ] Department of Radiation Oncology, University of Toronto and Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada.

[10 ] University of Calgary, Calgary, AB, Canada.

[11 ] Department of Oncology, Western University and London Regional Cancer Program, London, ON, Canada.

[12 ] BC Cancer - Surrey, BC, Canada.

[13 ] Department of Oncology, Division of Radiation Oncology, University of Alberta and Cross Cancer Institute, Edmonton, AB, Canada.

[14 ] Trillium Health Partners Credit Valley Hospital, Mississauga, ON, Canada.

[15 ] Department of Oncology, McGill University and Jewish General Hospital Segal Cancer Centre, Montreal, QC, Canada.

[16 ] Department of Physics and Astronomy, University of Victoria and BC Cancer - Victoria, BC, Canada.

[17 ] University of New South Wales and Prince of Wales Hospital, Sydney, NSW, Australia.

Article

Publisher Item ID: S0140-6736(19)32515-2

DOI: 10.1016/S0140-6736(19)32515-2

PubMed ID: 31813635

SO-VID: 3a146475-f862-4056-b21a-2adb5c6f10fc

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