Aging and eye tracking: in the quest for objective biomarkers

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Abstract

Recent applications of eye tracking for diagnosis, prognosis and follow-up of therapy in age-related neurological or psychological deficits have been reviewed. The review is focused on active aging, neurodegeneration and cognitive impairments. The potential impacts and current limitations of using characterizing features of eye movements and pupillary responses (oculometrics) as objective biomarkers in the context of aging are discussed. A closer look into the findings, especially with respect to cognitive impairments, suggests that eye tracking is an invaluable technique to study hidden aspects of aging that have not been revealed using any other noninvasive tool. Future research should involve a wider variety of oculometrics, in addition to saccadic metrics and pupillary responses, including nonlinear and combinatorial features as well as blink- and fixation-related metrics to develop biomarkers to trace age-related irregularities associated with cognitive and neural deficits.

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Most cited references 246

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Author and article information

Contributors

Parisa Gazerani: (View ORCID Profile)

Journal

Title: Future Neurology

Abbreviated Title: Future Neurology

Publisher: Future Medicine Ltd

ISSN (Print): 1479-6708

ISSN (Electronic): 1748-6971

Publication date Created: November 2019

Publication date (Print): November 2019

Volume: 14

Issue: 4

Page: FNL33

Affiliations

[1 ]Department of Health Science & Technology, Aalborg University, Aalborg E 9220, Denmark

Article

DOI: 10.2217/fnl-2019-0012

SO-VID: ae95b159-41dc-4dbe-acf9-ee684fe1955d

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