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      Intraocular pressure 1 year after vitrectomy in eyes without a history of glaucoma or ocular hypertension

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          Abstract

          Objective

          The aim of this study was to investigate the incidence, risk factors, and treatment of elevated intraocular pressure (IOP) 1 year after vitrectomy in eyes without a history of glaucoma or ocular hypertension.

          Patients and methods

          This retrospective study comprised 256 eyes from 256 consecutive patients without a history of glaucoma or ocular hypertension who underwent vitrectomy and were followed up for 1 year. The incidence of elevated IOP at 1 year after vitrectomy was calculated. We compared the characteristics of patients with or without elevated IOP to identify possible risk factors for elevated IOP. The treatments used to control IOP were recorded and analyzed.

          Results

          A total of 50 patients (19.5%) had elevated IOP after vitrectomy at the 1-year follow-up. Tamponade was a significant risk factor for elevated IOP ( P<0.05). The cumulative rates of elevated IOP in eyes with air, balanced salt solution, sulfur hexafluoride, perfluoropropane (C3F8), and silicone oil as the tamponade were 0, 10.8%, 5.9%, 19.8%, and 28.4%, respectively ( P<0.05). About 68% of cases of elevated IOP occurred within 1 month after vitrectomy. At 1 year after vitrectomy, 29 patients (58.0%) had stopped their IOP-lowering drugs and 21 (42.0%) patients were continuing these drugs. About 65% of ocular hypertension patients who received silicone oil tamponade had not stopped IOP-lowering drugs; this rate was significantly greater than that of ocular hypertension patients who received C3F8 tamponade (18.2%, P<0.05).

          Conclusion

          Elevated IOP is a common complication after vitrectomy. Silicone oil tamponade was associated with greater risk of elevated IOP and had long-term effects on IOP. Drugs and surgery were used to control IOP, and some patients required long-term IOP-lowering therapy.

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          Most cited references30

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          Glaucoma after pars plana vitrectomy and silicone oil injection for complicated retinal detachments.

          S Honavar, Sagar Goyal, L Dandona … (1998)
          To determine the incidence and associations of glaucoma after pars plana vitrectomy (PPV) and silicone oil injection (SOI) for complicated retinal detachments and the response to treatment. Retrospective noncomparative case series. A total of 150 eyes of 150 patients who had completed a minimum of 6 months of follow-up were included in this study. Analysis included clinical records of all consecutive cases of complicated retinal detachment that underwent PPV with SOI between July 1991 and February 1996. Surgical intervention for vitreoretinal pathology included standard three-port PPV and additional procedures as appropriate for the retinal pathology, and SOI. Procedures for the control of glaucoma were silicone oil removal (SOR), trabeculectomy with mitomycin C, cyclocryotherapy, semiconductor diode laser contact transscleral cyclophotocoagulation (TSCPC) and anterior chamber tube shunt to encircling band (ACTSEB). Presence of glaucoma (predefined as intraocular pressure [IOP] > or = 24 mmHg, which also was > or = 10 mmHg over the preoperative level, sustained for > or = 6 weeks) and the result of medical and surgical management were the main outcome measures. Demographic, preoperative, intraoperative, and postoperative parameters including the age of the patient, etiology of retinal detachment, refractive status, pre-existing glaucoma, aphakia, diabetes mellitus, presence of silicone oil (SO) in the anterior chamber, emulsification of SO, rubeosis iridis, and anatomic success were evaluated by univariate and multivariate logistic regression analyses to assess their predictive value in the causation of glaucoma and to determine factors prognosticating response to treatment. The main indications for PPV+SOI were proliferative vitreoretinopathy (57%; 85 of 150), proliferative diabetic retinopathy (15%; 23 of 150), and trauma (14%, 21 of 150). Glaucoma occurred in 60 eyes (40%) at 14 days median (range, 1 day-18 months). Elevation of IOP could be attributed directly to SO in 42 (70%) eyes. Glaucoma was controlled in 43 (72%) of 60 eyes on treatment (with medicines alone in 30%; SOR and medicines in 25%; trabeculectomy with mitomycin C/ACTSEB/cyclocryotherapy or TSCPC in 17%); 28% (17 of 60) remained refractory. Independent predictive factors for glaucoma on multivariate analysis were rubeosis iridis (odds ratio, 10.76), aphakia (odds ratio, 9.83), diabetes (odds ratio, 6.03), SO in anterior chamber (odds ratio, 4.74), and anatomic failure (negative risk factor; odds ratio, 0.11). Poor prognostic factors for the control of glaucoma were SO emulsification (odds ratio, 15.34) and diabetes (odds ratio, 6.03). Glaucoma is a frequent and often a refractory complication of PPV with SOI and has a multifactorial etiology. Aggressive medical and surgical management with SOR, trabeculectomy with mitomycin C, glaucoma shunts, and cyclodestructive procedures shows modest success in controlling IOP.
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            Incidence and management of elevated intraocular pressure after silicone oil injection.

            Bastawy M A Al Fawal, Steve Charles, Inger Netland (2005)
            To determine the incidence and clinical features of chronic elevated intraocular pressure after pars plana vitrectomy and silicone oil injection for complicated retinal detachments, and to evaluate the clinical management of eyes with secondary glaucoma. This was an observational consecutive case series of 450 eyes in 447 patients who were treated with pars plana vitrectomy and silicone oil injection. Patients who developed secondary glaucoma were treated medically with antiglaucoma medications and surgically with glaucoma drainage implants placed in an inferior quadrant. Main outcome measures were intraocular pressure, number of glaucoma medications, surgical success, and complications. Fifty-one of 450 eyes (11%) developed elevated intraocular pressure after pars plana vitrectomy and silicone oil injection whereas 399 eyes (89%) did not have a rise in intraocular pressure. Of the 51 eyes that developed elevated intraocular pressure, 40 (78%) were treated only with glaucoma medicines. Medical therapy reduced the intraocular pressure from a mean +/- SD of 26 +/- 13.4 mm Hg before treatment to 18 +/- 9.1 mm Hg after medical treatment (P = 0.002). The 11 of 51 eyes (22%) with elevated intraocular pressure that failed medical therapy were treated surgically with Ahmed Glaucoma Valve implantation within 12 months of silicone oil injection. In the surgical group, intraocular pressure was reduced from a mean +/- SD of 44 +/- 11.8 mm Hg before surgery to 14 +/- 4.2 mm Hg at the most recent follow-up after surgery (P < 0.001). The number of antiglaucoma medications was reduced from 3.5 +/- 0.7 before surgery to 1.2 +/- 0.5 at the most recent follow-up after surgery (P < 0.001). Chronic intraocular pressure elevation occurs in a minority (11%) of patients who are treated with silicone oil. Most of these eyes are effectively treated with antiglaucoma medications. Eyes that do not respond to medical therapy may be effectively managed with glaucoma drainage implant placement in an inferior quadrant.
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              Intraocular pressure and silicone oil endotamponade.

              Roland Knorr, Mark R. Rank, J. Jonas … (2001)
              To evaluate intraocular pressure after instillation and eventual removal of silicone oil in patients undergoing pars plana vitrectomy combined with silicone oil endotamponade. The study included 198 patients who underwent pars plana vitrectomy with silicone oil endotamponade (5,000 centistoke viscosity), in whom silicone oil was removed and in whom follow-up after oil removal was at least 3 months. All patients were operated on by one of two surgeons. After silicone oil instillation, intraocular pressure increased significantly (P 0.20) independent of the duration of silicone oil tamponade. Twenty percent of the 198 patients had at least one postoperative intraocular pressure measurement that was higher than 21 mm Hg. Main reasons for increased intraocular pressure were closed inferior iridectomy, iris neovascularisation, silicomacrophagocytic open-angle glaucoma secondary to silicone oil emulsification, and preoperative history of glaucoma. Glaucomatous optic nerve damage was detected in 14 (14 of 198, 7.1%) eyes, including 8 eyes with preoperative antiglaucoma treatment. Silicone oil emulsification occurring in 40 (40 of 198, 20.2%) patients did not statistically influence intraocular pressure after oil removal. Ocular hypotony occurred in 10 (10 of 198, 5.1%) patients after oil release leading to intraocular hemorrhages and loss of vision in 3 patients. Clinically significant increased intraocular pressure after pars plana vitrectomy with silicone oil endotamponade occurs relatively rarely, can usually be well controlled by topical antiglaucoma medication, and is reversible in most patients after oil removal. In patients with increased intraocular pressure and silicone oil endotamponade, oil removal may be preferred to invasive antiglaucoma surgery to reduce intraocular pressure.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Clin Ophthalmol
                Journal ID (iso-abbrev): Clin Ophthalmol
                Journal ID (publisher-id): Clinical Ophthalmology
                Title: Clinical Ophthalmology (Auckland, N.Z.)
                Publisher: Dove Medical Press
                ISSN (Print): 1177-5467
                ISSN (Electronic): 1177-5483
                Publication date Collection: 2017
                Publication date (Electronic): 22 November 2017
                Volume: 11
                Pages: 2091-2097
                Affiliations
                [1 ]Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai
                [2 ]Department of Ophthalmology, Jiangyin Bright Eye Hospital, Jiangyin, Jiangsu
                [3 ]State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science
                [4 ]Key Laboratory of Myopia, NHFPC (Fudan University)
                [5 ]Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, People’s Republic of China
                Author notes
                Correspondence: Xinghuai Sun, Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, 83 Fenyang Road, Shanghai 200031, People’s Republic of China, Tel +86 21 6437 7134, Fax +86 21 6437 7151, Email xhsun@ 123456shmu.edu.cn
                Article
                Publisher ID: opth-11-2091
                DOI: 10.2147/OPTH.S144985
                PMC ID: 5703171
                SO-VID: 2e7c2d8f-bbb9-49d5-8717-645d8e42db37
                Copyright © © 2017 Fang et al. This work is published and licensed by Dove Medical Press Limited
                License:

                The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                History
                Categories
                Subject: Original Research

                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: ocular hypertension,vitrectomy,silicone oil,glaucoma
                Data availability:
                ScienceOpen disciplines: Ophthalmology & Optometry
                Keywords: ocular hypertension, vitrectomy, silicone oil, glaucoma

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