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      Overview of popular cosmeceuticals in dermatology

      review-article
      Author(s): 1 , , 2 , 1
      Publication date (Electronic):
      Journal: Skin Health and Disease
      Publisher: John Wiley and Sons Inc.

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          Abstract

          The eternal pursuit to prevent ageing and maintain a youthful appearance has resulted in a rapidly expanding cosmeceutical industry. Cosmeceutical products, particularly of natural origin, are in high demand due to claims of efficacy for signs of ageing and other skin conditions. Consumers often include cosmeceutical products in their skin care regime as they are readily available, and a more affordable option compared to prescription products. However, many cosmeceutical ingredients lack clinical evidence regarding their efficacy and safety as these products are not regulated by the U.S. Food and Drug Administration. This review provides a brief overview of several popular cosmeceutical ingredients with regards to their potential indications, targets and mechanisms of action.

          Abstract

          Cosmeceutical products are often included in skin care regimes due to availability and affordability. However, many cosmeceutical ingredients lack clinical evidence. This article provides an overview of several popular cosmeceutical ingredients with regards to potential indications, targets and mechanisms of action.

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          Most cited references96

          • Record: found
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          Hyaluronic acid: A key molecule in skin aging

          Eleni Papakonstantinou, Michael Roth, George Karakiulakis (2012)
          Skin aging is a multifactorial process consisting of two distinct and independent mechanisms: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.
          Article 0 comments Cited 235 times – based on 0 reviews     Review now
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            Skin microbiota-host interactions.

            Y Chen, Michael A. Fischbach, Yasmine Belkaid (2018)
            The skin is a complex and dynamic ecosystem that is inhabited by bacteria, archaea, fungi and viruses. These microbes-collectively referred to as the skin microbiota-are fundamental to skin physiology and immunity. Interactions between skin microbes and the host can fall anywhere along the continuum between mutualism and pathogenicity. In this Review, we highlight how host-microbe interactions depend heavily on context, including the state of immune activation, host genetic predisposition, barrier status, microbe localization, and microbe-microbe interactions. We focus on how context shapes the complex dialogue between skin microbes and the host, and the consequences of this dialogue for health and disease.
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              Zinc in wound healing: theoretical, experimental, and clinical aspects.

              Alan B. G. Lansdown, Ursula Mirastschijski, Nicky Stubbs … (2007)
              Zinc is an essential trace element in the human body and its importance in health and disease is appreciated. It serves as a cofactor in numerous transcription factors and enzyme systems including zinc-dependent matrix metalloproteinases that augment autodebridement and keratinocyte migration during wound repair. Zinc confers resistance to epithelial apoptosis through cytoprotection against reactive oxygen species and bacterial toxins possibly through antioxidant activity of the cysteine-rich metallothioneins. Zinc deficiency of hereditary or dietary cause can lead to pathological changes and delayed wound healing. Oral zinc supplementation may be beneficial in treating zinc-deficient leg ulcer patients, but its therapeutic place in surgical patients needs further clarification. Topical administration of zinc appears to be superior to oral therapy due to its action in reducing superinfections and necrotic material via enhanced local defense systems and collagenolytic activity, and the sustained release of zinc ions that stimulates epithelialization of wounds in normozincemic individuals. Zinc oxide in paste bandages (Unna boot) protects and soothes inflamed peri-ulcer skin. Zinc is transported through the skin from these formulations, although the systemic effects seem insignificant. We present here the first comprehensive account of zinc in wound management in relation to current concepts of wound bed preparation and the wound-healing cascade. This review article suggests that topical zinc therapy is underappreciated even though clinical evidence emphasizes its importance in autodebridement, anti-infective action, and promotion of epithelialization.
              Article 0 comments Cited 177 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Chantalle Crous:
                ORCID: https://orcid.org/0000-0002-5603-4328
                21204756@mynwu.ac.za
                Journal
                Journal ID (nlm-ta): Skin Health Dis
                Journal ID (iso-abbrev): Skin Health Dis
                Journal ID (doi): 10.1002/(ISSN)2690-442X
                Journal ID (publisher-id): SKI2
                Title: Skin Health and Disease
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 2690-442X
                Publication date (Electronic): 07 February 2024
                Publication date Collection: April 2024
                Volume: 4
                Issue: 2 ( doiID: 10.1002/ski2.v4.2 )
                Electronic Location Identifier: e340
                Affiliations
                [ 1 ] Pharmaceutical Chemistry School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences North‐West University Potchefstroom South Africa
                [ 2 ] Biomedical Emporium Pretoria South Africa
                Author notes
                [*] [* ] Correspondence

                Chantalle Crous.

                Email: 21204756@ 123456mynwu.ac.za

                Author information
                https://orcid.org/0000-0002-5603-4328
                Article
                Publisher ID: SKI2340
                DOI: 10.1002/ski2.340
                PMC ID: 10988741
                PubMed ID: 38577050
                SO-VID: 8b6e35c5-34ad-412a-9dce-e2820d9e1d8d
                Copyright © © 2024 The Authors. Skin Health and Disease published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date revision received : 04 December 2023
                Date received : 09 October 2023
                Date accepted : 18 January 2024
                Page count
                Figures: 2, Tables: 4, Pages: 16, Words: 9506
                Funding
                Funded by: Biomedical Emporium
                Categories
                Subject: Review Article
                Subject: Review Articles
                Custom metadata
                source-schema-version-number 2.0
                cover-date April 2024
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:6.4.0 mode:remove_FC converted:03.04.2024

                Data availability:

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