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      Myocardial Matrix Hydrogels for Cardiac Repair : The Devil Is in the Details ∗

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          The extracellular matrix protein agrin promotes heart regeneration in mice

          Elad Bassat, Yara Mutlak, Alex Genzelinakh … (2017)
          The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the first week of life. Here we show that changes in the composition of the extracellular matrix during this week can affect cardiomyocyte
          Article 0 comments Cited 280 times – based on 0 reviews     Review now
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            First-in-Man Study of a Cardiac Extracellular Matrix Hydrogel in Early and Late Myocardial Infarction Patients

            Jay Traverse, Timothy D Henry, Nabil Dib … (2019)
            Article 0 comments Cited 90 times – based on 0 reviews     Review now
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              Safety and efficacy of an injectable extracellular matrix hydrogel for treating myocardial infarction.

              Sonya Seif-Naraghi, Jennifer M. Singelyn, Michael Salvatore … (2013)
              New therapies are needed to prevent heart failure after myocardial infarction (MI). As experimental treatment strategies for MI approach translation, safety and efficacy must be established in relevant animal models that mimic the clinical situation. We have developed an injectable hydrogel derived from porcine myocardial extracellular matrix as a scaffold for cardiac repair after MI. We establish the safety and efficacy of this injectable biomaterial in large- and small-animal studies that simulate the clinical setting. Infarcted pigs were treated with percutaneous transendocardial injections of the myocardial matrix hydrogel 2 weeks after MI and evaluated after 3 months. Echocardiography indicated improvement in cardiac function, ventricular volumes, and global wall motion scores. Furthermore, a significantly larger zone of cardiac muscle was found at the endocardium in matrix-injected pigs compared to controls. In rats, we establish the safety of this biomaterial and explore the host response via direct injection into the left ventricular lumen and in an inflammation study, both of which support the biocompatibility of this material. Hemocompatibility studies with human blood indicate that exposure to the material at relevant concentrations does not affect clotting times or platelet activation. This work therefore provides a strong platform to move forward in clinical studies with this cardiac-specific biomaterial that can be delivered by catheter.
              Article 0 comments Cited 61 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Javier Barallobre-Barreiro
                Journal
                Journal ID (nlm-ta): JACC Basic Transl Sci
                Journal ID (iso-abbrev): JACC Basic Transl Sci
                Title: JACC: Basic to Translational Science
                Publisher: Elsevier
                ISSN (Electronic): 2452-302X
                Publication date PMC-release: 28 March 2024
                Publication date Collection: March 2024
                Publication date (Electronic): 28 March 2024
                Volume: 9
                Issue: 3
                Pages: 339-341
                Affiliations
                [1]King’s British Heart Foundation Centre of Research Excellence, London, United Kingdom
                Author notes
                [∗ ] Address for correspondence: Dr Javier Barallobre-Barreiro, King’s British Heart Foundation Centre, King’s College London, 125 Coldharbour Lane, London SE5 9NU, United Kingdom. javier.barallobre-barreiro@ 123456kcl.ac.uk
                [∗]

                Editorials published in JACC: Basic to Translational Science reflect the views of the authors and do not necessarily represent the views of JACC: Basic to Translational Science or the American College of Cardiology.

                Article
                Publisher Item ID: S2452-302X(24)00038-X
                DOI: 10.1016/j.jacbts.2024.02.001
                PMC ID: 10978399
                PubMed ID: 38559625
                SO-VID: 9dc34b7f-5cb5-4aea-ad97-78c9d8d26f6a
                Copyright © © 2024 The Authors
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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                Categories
                Subject: Original Research - Preclinical
                Subject: Editorial Comment

                Keywords: biomaterial,extracellular matrix,hydrogel,negative right ventricle remodeling,proteomics
                Data availability:
                Keywords: biomaterial, extracellular matrix, hydrogel, negative right ventricle remodeling, proteomics

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