Survival in synucleinopathies: A prospective cohort study.

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Abstract

Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic failure (PAF) involve cytoplasmic deposition of α-synuclein and are considered to be synucleinopathies. Approximately 40% of patients with PD, most patients with MSA, and all patients with PAF have neurogenic orthostatic hypotension (OH). This study compared long-term survival in these synucleinopathies.

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Journal

Journal ID (iso-abbrev): Neurology

Title: Neurology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1526-632X

ISSN (Print): 0028-3878

Publication date (Electronic): Nov 03 2015

Volume: 85

Issue: 18

Affiliations

[1 ] From the Clinical Neurocardiology Section (D.S.G., C.H.) and Office of the Clinical Director (T.W.), Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; and Hypertension Unit (Y.S.), Chaim Sheba Medical Center and Tel Aviv University, Tel HaShomer, Israel. goldsteind@ninds.nih.gov.

[2 ] From the Clinical Neurocardiology Section (D.S.G., C.H.) and Office of the Clinical Director (T.W.), Clinical Neurosciences Program, Division of Intramural Research, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; and Hypertension Unit (Y.S.), Chaim Sheba Medical Center and Tel Aviv University, Tel HaShomer, Israel.

Article

Publisher Item ID: WNL.0000000000002086

DOI: 10.1212/WNL.0000000000002086

PMC ID: 4642141

PubMed ID: 26432848

SO-VID: da12375a-1a17-4922-ba62-cccf180e2a07

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