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      Calcium signaling.

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      Cell

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          Abstract

          Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.

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          Author and article information

          Journal
          Cell
          Cell
          0092-8674
          0092-8674
          Dec 14 2007
          : 131
          : 6
          Affiliations
          [1 ] Aldo R. Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children's Hospital Boston, Boston, MA 02115, USA. dclapham@enders.tch.harvard.edu
          Article
          S0092-8674(07)01531-0
          10.1016/j.cell.2007.11.028
          18083096
          d39c39d5-5c4b-4e07-b7cb-c5b6ac077f85
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