Luke R. Joyce:
ORCID: https://orcid.org/0000-0002-9346-671X
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: ValidationRole: Writing – original draftRole: Writing – review &
editing
Haider S. Manzer:
ORCID: https://orcid.org/0000-0002-2864-6212
Role: Data curationRole: Formal analysisRole: Writing – review & editing
Jéssica da C. Mendonça:
ORCID: https://orcid.org/0000-0002-2555-4582
Role: Data curationRole: Formal analysisRole: Writing – review & editing
Ricardo Villarreal:
ORCID: https://orcid.org/0000-0001-7641-4136
Role: Data curationRole: Formal analysisRole: Writing – review & editing
Prescilla E. Nagao:
ORCID: https://orcid.org/0000-0001-6007-0033
Role: Funding acquisitionRole: Supervision
Kelly S. Doran:
ORCID: https://orcid.org/0000-0003-4232-6837
Role: ConceptualizationRole: Funding acquisitionRole: ResourcesRole: SupervisionRole:
Writing – review & editing
Kelli L. Palmer:
ORCID: https://orcid.org/0000-0002-7343-9271
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
ResourcesRole: SupervisionRole: ValidationRole: Writing – review & editing
Ziqiang Guan:
ORCID: https://orcid.org/0000-0002-8082-3423
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
MethodologyRole: Writing – review & editing
Matthew K. Waldor: Role: Academic Editor
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
18
February
2022
Publication date Collection:
February
2022
Publication date PMC-release: 18
February
2022
Volume: 20
Issue: 2
Electronic Location Identifier: e3001555
Affiliations
[1
]
Department of Biological Sciences, The University of Texas at Dallas, Richardson,
Texas, United States of America
[2
]
Department of Immunology and Microbiology, University of Colorado School of Medicine,
Aurora, Colorado, United States of America
[3
]
Rio de Janeiro State University, Roberto Alcântara Gomes Biology Institute, Rio de
Janeiro, Rio de Janeiro, Brazil
[4
]
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina,
United States of America
Brigham and Women’s Hospital, UNITED STATES
Author notes
The authors have declared that no competing interests exist
Author information
Article
Publisher ID:
PBIOLOGY-D-21-02630
DOI: 10.1371/journal.pbio.3001555
PMC ID: 8893666
PubMed ID: 35180210
SO-VID: 73f09385-d885-4757-a03e-95cd92ee53c8
Copyright © © 2022 Joyce et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: 5T32AI052066-18
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2864-6212
Haider S. Manzer
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: F31 AI164674
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2864-6212
Haider S. Manzer
Funded by:
funder-id http://dx.doi.org/10.13039/501100002322, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior;
Award ID: finance code 001
Award Recipient
:
ORCID: https://orcid.org/0000-0002-2555-4582
Jéssica da C. Mendonça
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R01NS116716
Award Recipient
:
ORCID: https://orcid.org/0000-0003-4232-6837
Kelly S. Doran
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R01AI153332
Award Recipient
:
ORCID: https://orcid.org/0000-0003-4232-6837
Kelly S. Doran
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R21AI130666
Award Recipient
:
ORCID: https://orcid.org/0000-0002-7343-9271
Kelli Palmer
Funded by:
Cecil H. and Ida Green Chair in Systems Biology Science
Award Recipient
:
ORCID: https://orcid.org/0000-0002-7343-9271
Kelli Palmer
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R01NS116716 - Supplement
Award Recipient
:
ORCID: https://orcid.org/0000-0001-7641-4136
Ricardo Villarreal
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R56AI139105
Award Recipient
:
ORCID: https://orcid.org/0000-0002-7343-9271
Kelli Palmer
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R56AI139105
Award Recipient
:
ORCID: https://orcid.org/0000-0002-8082-3423
Ziqiang Guan
Funded by:
funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: U54GM069338
Award Recipient
:
ORCID: https://orcid.org/0000-0002-8082-3423
Ziqiang Guan
The work was supported in part by the National Institutes of Health (
https://www.niaid.nih.gov/) training grant T32 5T32AI052066-18 and F31 AI164674 to H.S.M, the Coordenação de
Aperfeiçoamento de Pessoal de Nível Superior, Brazil (
https://www.gov.br/capes/pt-br) (CAPES; finance code 001) to J.D.C.M, by grants R01NS116716 and R01AI153332 from
the National Institutes of Health (
https://www.niaid.nih.gov/ and
https://www.ninds.nih.gov/) to K.S.D and associated NIH/NINDS supplement from R01NS116716 to R.V, National Institutes
of Health (
https://www.niaid.nih.gov/) grant R21AI130666 and the Cecil H. and Ida Green Chair in Systems Biology Science
to K.P, National Institutes of Health (
https://www.niaid.nih.gov/) grant R56AI139105 to K.P and Z.G, and National Institutes of Health grant U54GM069338
to Z.G. The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Discovery Report
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Bacterial Pathogens
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Bacterial Pathogens
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Streptococcus
Subject:
Group B streptococci
Subject:
Streptococcus Agalactiae
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Bacterial pathogens
Subject:
Streptococcus
Subject:
Group B streptococci
Subject:
Streptococcus Agalactiae
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Bacterial pathogens
Subject:
Streptococcus
Subject:
Group B streptococci
Subject:
Streptococcus Agalactiae
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Infectious Diseases of the Nervous System
Subject:
Meningitis
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Infectious Diseases of the Nervous System
Subject:
Meningitis
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Inflammatory Diseases
Subject:
Meningitis
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogenesis
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Glycobiology
Subject:
Glycolipids
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Basic Amino Acids
Subject:
Lysine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Amino Acids
Subject:
Basic Amino Acids
Subject:
Lysine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Amino Acids
Subject:
Basic Amino Acids
Subject:
Lysine