Predictors of response to omalizumab and relapse in chronic spontaneous urticaria: a study of 470 patients.

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Abstract

Chronic spontaneous urticaria (CSU) is defined as spontaneous occurrence of wheals and/or angioedema for ≥6 weeks. Omalizumab is a monoclonal anti-IgE antibody effective in refractory CSU, but its mechanism of action and markers predictive of response remain not completely defined.

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Author and article information

Journal

Journal ID (iso-abbrev): J Eur Acad Dermatol Venereol

Title: Journal of the European Academy of Dermatology and Venereology : JEADV

Publisher: Wiley

ISSN (Electronic): 1468-3083

ISSN (Print): 0926-9959

Publication date (Electronic): May 2019

Volume: 33

Issue: 5

Affiliations

[1 ] UOC Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

[2 ] Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

[3 ] Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Università degli Studi di Milano, Milan, Italy.

[4 ] Department of Medical Sciences, Section of Dermatology, University of Turin, Turin, Italy.

[5 ] Department of Clinical and Experimental Medicine-Respiratory Medicine & Allergy, University of Catania, Catania, Italy.

[6 ] Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

[7 ] Clinical Dermatology, Department of Biomedical, Surgical and Dental Sciences, IRCCS Galeazzi Orthopaedic Institute, University of Milan, Milan, Italy.

[8 ] Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

[9 ] Department of Medicine, Section of Dermatology, University of Verona, Verona, Italy.

[10 ] Department of Biomedical Science and Human Oncology, Section of Dermatology, University of Bari, Bari, Italy.

[11 ] Section of Clinical, Allergological and Venereological Dermatology, Department of Medicine, University of Perugia, Perugia, Italy.

[12 ] Service of Occupational and Environmental Allergic Dermatology, San Gallicano Dermatology Institute for Research and Care, Rome, Italy.

[13 ] Department of Internal Medicine, Respiratory Disease Clinic, IRCCS Humanitas Clinical and Research Center, Humanitas University, Milan, Italy.

[14 ] Department of Emergency and Organ Transplantation, School of Allergology and Clinical Immunology, University of Bari Aldo Moro, Bari, Italy.

[15 ] Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Milan, Italy.

Article

DOI: 10.1111/jdv.15350

PubMed ID: 30451325

SO-VID: 4c0bc3f1-ba8a-4f5a-9e39-607e055658aa

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