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      First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer

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          Abstract

          Enhancing tumor-specific T-cell immunity by inhibiting programmed death ligand 1 (PD-L1)-programmed death 1 (PD-1) signaling has shown promise in the treatment of extensive-stage small-cell lung cancer. Combining checkpoint inhibition with cytotoxic chemotherapy may have a synergistic effect and improve efficacy.

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          A Confidence Interval for the Median Survival Time

          Ron Brookmeyer, John Crowley (1982)
          Article 0 comments Cited 149 times – based on 0 reviews     Review now
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            Current standards for clinical management of small cell lung cancer

            Anna Farago, Florence Keane (2018)
            Small cell lung cancer (SCLC) is an aggressive high-grade neuroendocrine carcinoma. Despite over 30 years of clinical research, little progress has been made in the management of SCLC, and outcomes remain poor. Here, we review the current clinical standards for management of SCLC and the data supporting these strategies.
            Article 0 comments Cited 104 times – based on 0 reviews     Review now
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              Phase II Study of Maintenance Pembrolizumab in Patients with Extensive-Stage Small Cell Lung Cancer (SCLC)

              Shirish Gadgeel, Nathan A. Pennell, Mary Jo Fidler … (2018)
              The aim of this study was to assess the efficacy of maintenance pembrolizumab in patients with extensive-stage SCLC after treatment with platinum and etoposide.
              Article 0 comments Cited 103 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: New England Journal of Medicine
                Abbreviated Title: N Engl J Med
                Publisher: New England Journal of Medicine (NEJM/MMS)
                ISSN (Print): 0028-4793
                ISSN (Electronic): 1533-4406
                Publication date Created: September 25 2018
                Publication date (Electronic): September 25 2018
                Affiliations
                [1 ]From Vanderbilt University Medical Center (L. Horn) and Sarah Cannon Research Institute–Tennessee Oncology (M.L.J.), Nashville; Mayo Clinic, Rochester, MN (A.S.M.); Mazowieckie Centrum Leczenia Chorób Płuc i Gruźlicy, Otwock (A. Szczęsna), and Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie, Warsaw (M.K.) — both in Poland; Thomayerova Nemocnice, Pneumologická Klinika 1.LF UK, Prague, Czech Republic (L. Havel); the Department of Respiratory and Critical Care Medicine (M.J.H.) and the...
                Article
                DOI: 10.1056/NEJMoa1809064
                SO-VID: aef4af81-34de-48bf-8d46-862c25076cef
                Copyright © © 2018
                License:

                http://www.nejmgroup.org/legal/terms-of-use.htm

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