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      The impact of exposure to air pollution on cognitive performance

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          Significance

          Most of the population in developing countries live in places with unsafe air. Utilizing variations in transitory and cumulative air pollution exposures for the same individuals over time in China, we provide evidence that polluted air may impede cognitive ability as people become older, especially for less educated men. Cutting annual mean concentration of particulate matter smaller than 10 μm (PM10) in China to the Environmental Protection Agency’s standard (50 μg/m 3) would move people from the median to the 63rd percentile (verbal test scores) and the 58th percentile (math test scores), respectively. The damage on the aging brain by air pollution likely imposes substantial health and economic costs, considering that cognitive functioning is critical for the elderly for both running daily errands and making high-stake decisions.

          Abstract

          This paper examines the effect of both cumulative and transitory exposures to air pollution for the same individuals over time on cognitive performance by matching a nationally representative longitudinal survey and air quality data in China according to the exact time and geographic locations of the cognitive tests. We find that long-term exposure to air pollution impedes cognitive performance in verbal and math tests. We provide evidence that the effect of air pollution on verbal tests becomes more pronounced as people age, especially for men and the less educated. The damage on the aging brain by air pollution likely imposes substantial health and economic costs, considering that cognitive functioning is critical for the elderly for both running daily errands and making high-stake decisions.

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          Most cited references13

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          The global burden of disease due to outdoor air pollution.

          As part of the World Health Organization (WHO) Global Burden of Disease Comparative Risk Assessment, the burden of disease attributable to urban ambient air pollution was estimated in terms of deaths and disability-adjusted life years (DALYs). Air pollution is associated with a broad spectrum of acute and chronic health effects, the nature of which may vary with the pollutant constituents. Particulate air pollution is consistently and independently related to the most serious effects, including lung cancer and other cardiopulmonary mortality. The analyses on which this report is based estimate that ambient air pollution, in terms of fine particulate air pollution (PM(2.5)), causes about 3% of mortality from cardiopulmonary disease, about 5% of mortality from cancer of the trachea, bronchus, and lung, and about 1% of mortality from acute respiratory infections in children under 5 yr, worldwide. This amounts to about 0.8 million (1.2%) premature deaths and 6.4 million (0.5%) years of life lost (YLL). This burden occurs predominantly in developing countries; 65% in Asia alone. These estimates consider only the impact of air pollution on mortality (i.e., years of life lost) and not morbidity (i.e., years lived with disability), due to limitations in the epidemiologic database. If air pollution multiplies both incidence and mortality to the same extent (i.e., the same relative risk), then the DALYs for cardiopulmonary disease increase by 20% worldwide.
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            The Impact of Air Pollution on Infant Mortality: Evidence from Geographic Variation in Pollution Shocks Induced by a Recession

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              The outdoor air pollution and brain health workshop.

              Accumulating evidence suggests that outdoor air pollution may have a significant impact on central nervous system (CNS) health and disease. To address this issue, the National Institute of Environmental Health Sciences/National Institute of Health convened a panel of research scientists that was assigned the task of identifying research gaps and priority goals essential for advancing this growing field and addressing an emerging human health concern. Here, we review recent findings that have established the effects of inhaled air pollutants in the brain, explore the potential mechanisms driving these phenomena, and discuss the recommended research priorities/approaches that were identified by the panel. Copyright © 2012 Elsevier Inc. All rights reserved.
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                Author and article information

                Journal
                Proc Natl Acad Sci U S A
                Proc. Natl. Acad. Sci. U.S.A
                pnas
                pnas
                PNAS
                Proceedings of the National Academy of Sciences of the United States of America
                National Academy of Sciences
                0027-8424
                1091-6490
                11 September 2018
                27 August 2018
                : 115
                : 37
                : 9193-9197
                Affiliations
                [1] aSchool of Statistics, Beijing Normal University , Beijing 100875, China;
                [2] bDepartment of Health Policy and Management, Yale School of Public Health , New Haven, CT 06520;
                [3] cDepartment of Economics, Yale University , New Haven, CT 06511;
                [4] dNational School of Development, Peking University , Beijing 100871, China;
                [5] eDivision of Development Strategy and Governance, International Food Policy Research Institute , Washington, DC 20005
                Author notes
                2To whom correspondence should be addressed. Email: x.zhang@ 123456nsd.pku.edu.cn .

                Edited by Robert M. Hauser, Center for Demography of Health and Aging, Madison, WI, and approved July 23, 2018 (received for review June 8, 2018)

                Author contributions: X.C. and Xiaobo Zhang designed research; Xin Zhang, X.C., and Xiaobo Zhang performed research; Xin Zhang analyzed data; and Xin Zhang, X.C., and Xiaobo Zhang wrote the paper.

                1Xin Zhang and X.C. contributed equally to this work.

                Author information
                http://orcid.org/0000-0003-0184-5868
                http://orcid.org/0000-0002-4981-9565
                Article
                PMC6140474 PMC6140474 6140474 201809474
                10.1073/pnas.1809474115
                6140474
                30150383
                3c9b5e67-243e-4744-adb8-0146658898a5
                Copyright @ 2018

                Published under the PNAS license.

                History
                Page count
                Pages: 5
                Funding
                Funded by: US Federal PEPPER Center Career Development Award
                Award ID: P30AG021342
                Award Recipient : Xi Chen
                Funded by: NIH/NIA
                Award ID: 1 R03 AG048920
                Award Recipient : Xi Chen
                Funded by: NIH/NIA
                Award ID: K01AG053408
                Award Recipient : Xi Chen
                Funded by: China Postdoctoral Science Foundation 501100002858
                Award ID: 2017M620653
                Award Recipient : Xin Zhang
                Categories
                9
                Social Sciences
                Psychological and Cognitive Sciences
                Sustainability Science

                aging,gender difference,China,cognitive decline,air pollution

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