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      Chronic kidney disease in low- and middle-income countries

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          Abstract

          Most of the global burden of chronic kidney disease (CKD) is occurring in low- and middle-income countries (LMICs). As a result of rapid urbanization in LMICs, a growing number of populations are exposed to numerous environmental toxins, high infectious disease burdens and increasing rates of noncommunicable diseases. For CKD, this portends a high prevalence related to numerous etiologies, and it presents unique challenges. A better understanding of the epidemiology of CKD in LMICs is urgently needed, but this must be coupled with strong public advocacy and broad, collaborative public health efforts that address environmental, communicable, and non-communicable risk factors.

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          Most cited references75

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          Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

          The Lancet, 385(9963), 117-171
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            Chronic kidney disease: global dimension and perspectives.

            Chronic kidney disease is defined as a reduced glomerular filtration rate, increased urinary albumin excretion, or both, and is an increasing public health issue. Prevalence is estimated to be 8-16% worldwide. Complications include increased all-cause and cardiovascular mortality, kidney-disease progression, acute kidney injury, cognitive decline, anaemia, mineral and bone disorders, and fractures. Worldwide, diabetes mellitus is the most common cause of chronic kidney disease, but in some regions other causes, such as herbal and environmental toxins, are more common. The poorest populations are at the highest risk. Screening and intervention can prevent chronic kidney disease, and where management strategies have been implemented the incidence of end-stage kidney disease has been reduced. Awareness of the disorder, however, remains low in many communities and among many physicians. Strategies to reduce burden and costs related to chronic kidney disease need to be included in national programmes for non-communicable diseases. Copyright © 2013 Elsevier Ltd. All rights reserved.
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              Prevalence of chronic kidney disease in China: a cross-sectional survey.

              The prevalence of chronic kidney disease is high in developing countries. However, no national survey of chronic kidney disease has been done incorporating both estimated glomerular filtration rate (eGFR) and albuminuria in a developing country with the economic diversity of China. We aimed to measure the prevalence of chronic kidney disease in China with such a survey. We did a cross-sectional survey of a nationally representative sample of Chinese adults. Chronic kidney disease was defined as eGFR less than 60 mL/min per 1·73 m(2) or the presence of albuminuria. Participants completed a lifestyle and medical history questionnaire and had their blood pressure measured, and blood and urine samples taken. Serum creatinine was measured and used to estimate glomerular filtration rate. Urinary albumin and creatinine were tested to assess albuminuria. The crude and adjusted prevalence of indicators of kidney damage were calculated and factors associated with the presence of chronic kidney disease analysed by logistic regression. 50,550 people were invited to participate, of whom 47,204 agreed. The adjusted prevalence of eGFR less than 60 mL/min per 1·73 m(2) was 1·7% (95% CI 1·5-1·9) and of albuminuria was 9·4% (8·9-10·0). The overall prevalence of chronic kidney disease was 10·8% (10·2-11·3); therefore the number of patients with chronic kidney disease in China is estimated to be about 119·5 million (112·9-125·0 million). In rural areas, economic development was independently associated with the presence of albuminuria. The prevalence of chronic kidney disease was high in north (16·9% [15·1-18·7]) and southwest (18·3% [16·4-20·4]) regions compared with other regions. Other factors independently associated with kidney damage were age, sex, hypertension, diabetes, history of cardiovascular disease, hyperuricaemia, area of residence, and economic status. Chronic kidney disease has become an important public health problem in China. Special attention should be paid to residents in economically improving rural areas and specific geographical regions in China. The Ministry of Science and Technology (China); the Science and Technology Commission of Shanghai; the National Natural Science Foundation of China; the Department of Health, Jiangsu Province; the Sichuan Science and Technology Department; the Ministry of Education (China); the International Society of Nephrology Research Committee; and the China Health and Medical Development Foundation. Copyright © 2012 Elsevier Ltd. All rights reserved.
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                Author and article information

                Journal
                Nephrol Dial Transplant
                Nephrol. Dial. Transplant
                ndt
                ndt
                Nephrology Dialysis Transplantation
                Oxford University Press
                0931-0509
                1460-2385
                June 2016
                04 February 2016
                1 June 2017
                : 31
                : 6
                : 868-874
                Affiliations
                [1 ] Division of Nephrology, Department of Medicine, Duke University , Durham, NC, USA
                [2 ] Duke Global Health Institute, Duke University , Durham, NC, USA
                [3 ] Duke Clinical Research Institute, Duke University , Durham, NC, USA
                [4 ] Department of Medicine, Massachusetts General Hospital , Boston, MA, USA
                [5 ] Health Services and Systems Research, Duke-NUS Graduate Medical School , Singapore
                Author notes
                Correspondence and offprint requests to: John W. Stanifer; E-mail: john.stanifer@ 123456duke.edu
                Article
                PMC4876969 PMC4876969 4876969 gfv466
                10.1093/ndt/gfv466
                4876969
                27217391
                82d79dce-df6a-41b3-ba88-5bcdfe54935a
                © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
                History
                : 19 November 2015
                : 30 December 2015
                Funding
                Funded by: National Institute of Diabetes, Digestive and Kidney Diseases
                Funded by: National Institutes of Health http://dx.doi.org/10.13039/100000002
                Award ID: R01DK93938, R34DK102166 and P30DK096493
                Categories
                Cutting-Edge Renal Science
                Ndt Perspectives

                noncommunicable diseases,urbanization,multidisciplinary,epidemiology

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