Research capacities in African universities are less developed due to many challenges — poor research infrastructure, limited Information and Communication Technologies (ICTs), the lack of leadership mandate and support, the lack of congenial political and academic environment in some countries, shortage and lack of faculty to pursue academic research due to heavy teaching loads, inadequate financial support, etc. This paper discusses the challenges facing higher education research in Africa. Using research reports, policy papers, and data in the Science Citation Index Expanded (SCI-EXPANDED), the Arts & Humanities Citation Index (A&HCI) and the Social Sciences Citation Index (SSCI) from Thompson’s Web of Science, this paper discusses the state of academic research in Africa. The author argues that for the continent of Africa to experience socioeconomic development, universities and research institutes need robust research agendas that will unleash to their economies the knowledge, ideas, innovation, and technologies for economic growth.