Anastasia Minenkova: Role: Data curationRole: ResourcesRole: ValidationRole: Writing – original draftRole:
Writing – review & editing
Erwin E. W. Jansen: Role: InvestigationRole: ResourcesRole: ValidationRole: Writing – review & editing
Jessie Cameron: Role: Formal analysisRole: ResourcesRole: Writing – review & editing
Rob Barto: Role: Formal analysisRole: ResourcesRole: ValidationRole: Writing – review & editing
Thomas Hurd: Role: InvestigationRole: ResourcesRole: ValidationRole: Writing – review & editing
Lauren MacNeil: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Gajja S. Salomons: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Saadet Mercimek-Andrews:
ORCID: https://orcid.org/0000-0001-8396-6764
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Israel Silman: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
8
September
2021
Publication date Collection: 2021
Volume: 16
Issue: 9
Electronic Location Identifier: e0257073
Affiliations
[1
]
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
[2
]
Metabolic Unit, Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit
Amsterdam, Amsterdam Neuroscience, Amsterdam Gastroenterology & Metabolism, Amsterdam,
The Netherlands
[3
]
Metabolic Laboratory, Department of Pediatric Laboratory Medicine, The Hospital for
Sick Children, Toronto, Ontario, Canada
[4
]
Department of Pediatric Laboratory Medicine, University of Toronto, Toronto, Ontario,
Canada
[5
]
Department of Medical Genetics, University of Alberta, Edmonton, Alberta, Canada
[6
]
Laboratory Genetic Metabolic Diseases, Department of Clinical Chemistry, Amsterdam
UMC, University of Amsterdam, Amsterdam Neuroscience, Amsterdam Gastroenterology &
Metabolism, Amsterdam, The Netherlands
[7
]
Division of Clinical and Metabolic Genetics, Department of Pediatrics, University
of Toronto, Toronto, Ontario, Canada
[8
]
The Hospital for Sick Children, Toronto, Ontario, Canada
Weizmann Institute of Science, ISRAEL
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-20-40994
DOI: 10.1371/journal.pone.0257073
PMC ID: 8425566
SO-VID: 98458fb1-d139-4ba8-b24f-75445b6e06bc
Copyright © © 2021 Minenkova et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
University of Toronto
Award Recipient
:
ORCID: https://orcid.org/0000-0001-8396-6764
Saadet Mercimek-Andrews
SMA was funded by the Department of Pediatrics at the University of Toronto. The funders
had no role in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
Subject:
Research Article
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Zebrafish
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Zebrafish
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Zebrafish
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Fish
Subject:
Osteichthyes
Subject:
Zebrafish
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Fish
Subject:
Osteichthyes
Subject:
Zebrafish
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Vitamins
Subject:
B Vitamins
Subject:
Pyridoxine
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Vitamins
Subject:
B Vitamins
Subject:
Pyridoxine
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolic Processes
Subject:
Citric Acid Cycle
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolic Pathways
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Bioenergetics
Subject:
Electron Transport Chain
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Neurochemistry
Subject:
Neurotransmitters
Subject:
Gamma-Aminobutyric Acid
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neurochemistry
Subject:
Neurotransmitters
Subject:
Gamma-Aminobutyric Acid
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolites
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Cerebrospinal Fluid
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Cerebrospinal Fluid
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Cerebrospinal Fluid
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Cerebrospinal Fluid
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Cerebrospinal Fluid