Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan-produced indole metabolites.

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Abstract

Membranous nephropathy (MN) is an immune-mediated glomerular disease in adults. Antibody- and antigen-bonding mechanisms have been largely clarified, but the subepithelium immune complex deposition-mediated downstream molecular mechanisms are currently unresolved. Increasing evidence has suggested that gut microbiota contribute to MN pathogenesis.

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The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Nathalie Percie Du Sert, Viki Hurst, Amrita Ahluwalia … (2021)

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the “ARRIVE Essential 10,” which constitutes the minimum requirement, and the “Recommended Set,” which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration (E&E) document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.

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Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.

Teresa Zelante, Rossana Iannitti, Cristina Cunha … (2013)

Endogenous tryptophan (Trp) metabolites have an important role in mammalian gut immune homeostasis, yet the potential contribution of Trp metabolites from resident microbiota has never been addressed experimentally. Here, we describe a metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice. Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription. The resulting IL-22-dependent balanced mucosal response allows for survival of mixed microbial communities yet provides colonization resistance to the fungus Candida albicans and mucosal protection from inflammation. Thus, the microbiota-AhR axis might represent an important strategy pursued by coevolutive commensalism for fine tuning host mucosal reactivity contingent on Trp catabolism. Copyright © 2013 Elsevier Inc. All rights reserved.

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Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers.

Michael J. Curtis, Steve A. Alexander, Giuseppe Cirino … (2018)

This article updates the guidance published in 2015 for authors submitting papers to British Journal of Pharmacology (Curtis et al., 2015) and is intended to provide the rubric for peer review. Thus, it is directed towards authors, reviewers and editors. Explanations for many of the requirements were outlined previously and are not restated here. The new guidelines are intended to replace those published previously. The guidelines have been simplified for ease of understanding by authors, to make it more straightforward for peer reviewers to check compliance and to facilitate the curation of the journal's efforts to improve standards.

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Author and article information

Journal

Journal ID (iso-abbrev): Br J Pharmacol

Title: British journal of pharmacology

Publisher: Wiley

ISSN (Electronic): 1476-5381

ISSN (Print): 0007-1188

Publication date (Electronic): Jan 2024

Volume: 181

Issue: 1

Affiliations

[1 ] School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China.

[2 ] Department of Nephrology, Shaanxi Traditional Chinese Medicine Hospital, Xi'an, China.

[3 ] School of Food and Bioengineering, Chengdu University, Chengdu, China.

[4 ] Department of Public Health and Sciences, University of Miami, Miami, Florida, USA.

[5 ] Department of Nephrology, Baoji Central Hospital, Baoji, China.

[6 ] Department of Urology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Article

DOI: 10.1111/bph.16219

PubMed ID: 37594378

SO-VID: e6bcd4ce-0fea-4601-a1e4-08ee8759d27b

History

Keywords: gut microbiota,idiopathic membranous nephropathy,indole-3-aldehyde,tryptophan metabolites,Lactobacillus,aryl hydrocarbon receptor

Data availability:

Keywords: gut microbiota, idiopathic membranous nephropathy, indole-3-aldehyde, tryptophan metabolites, Lactobacillus, aryl hydrocarbon receptor

Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan-produced indole metabolites.

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Most cited references 63

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers.

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