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      Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial.

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          Abstract

          Chikungunya is an emerging arthropod-borne disease that has spread from tropical endemic areas to more temperate climates of the USA and Europe. However, no specific treatment or preventive measure is yet available. We aimed to investigate the immunogenicity and safety of a live recombinant measles-virus-based chikungunya vaccine.

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          Author and article information

          Journal
          Lancet Infect Dis
          The Lancet. Infectious diseases
          1474-4457
          1473-3099
          May 2015
          : 15
          : 5
          Affiliations
          [1 ] Themis Bioscience GmbH, Vienna, Austria.
          [2 ] Department of Clinical Pharmacology, Medical University of Vienna, Austria, Europe.
          [3 ] Walter Reed Army Institute of Research, Viral Diseases Branch, Silver Springs, MD, USA.
          [4 ] Department of Infections and Epidemiology, Institut Pasteur, La Réunion, UMR U1187 PIMIT (I2T), France.
          [5 ] Department of Clinical Pharmacology, Medical University of Vienna, Austria, Europe. Electronic address: bernd.jilma@meduniwien.ac.at.
          [6 ] Viral Genomics and Vaccination Unit, Institut Pasteur, Paris, CNRS UMR-3569, France.
          Article
          S1473-3099(15)70043-5
          10.1016/S1473-3099(15)70043-5
          25739878
          b2541345-bf5c-412a-88b1-4a1cd2a395a6
          Copyright © 2015 Elsevier Ltd. All rights reserved.
          History

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