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      Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: A randomized clinical trial.

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          Abstract

          Impaired awareness of hypoglycemia (IAH) is a limiting factor in the treatment of type 1 diabetes (T1D) and is a challenging condition to reverse. The objective of this study was to test the hypothesis that naltrexone therapy in subjects with T1D and IAH will improve counterregulatory hormone response and recognition of hypoglycemia symptoms during hypoglycemia.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): J. Diabetes Complicat.
          Title: Journal of diabetes and its complications
          Publisher: Elsevier BV
          ISSN (Electronic): 1873-460X
          ISSN (Print): 1056-8727
          Publication date (Electronic): September 9 2015
          Volume: 29
          Issue: 8
          Affiliations
          [1 ] Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, Minneapolis, MN, United States. Electronic address: mohee002@umn.edu.
          [2 ] Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States.
          [3 ] Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
          [4 ] Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
          Article
          Publisher Item ID: S1056-8727(15)00349-9 Mid ID: NIHMS780434
          DOI: 10.1016/j.jdiacomp.2015.08.004
          PMC ID: 4871128
          PubMed ID: 26345338
          SO-VID: ade16136-ef6f-4fe0-962f-ea415ee893a5
          History

          Keywords: Hypoglycemia,HAAF,Impaired awareness of hypoglycemia,Naltrexone,Opioid antagonists,Type 1 diabetes
          Data availability:
          Keywords: Hypoglycemia, HAAF, Impaired awareness of hypoglycemia, Naltrexone, Opioid antagonists, Type 1 diabetes

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