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      SARS-CoV-2 seroprevalence among parturient women in Philadelphia.

      Author(s): 1 , 2 , 3 , 4 , 1 , 3 , 1 , 2 , 3 , 1 , 1 , 2 , 3 , 5 , 4 , 4 , 4 , 4 , 4 , 6 , 7 , 6 , 7 , 6 , 7 , 6 , 8 , 6 , 7 , 6 , 7 , 6 , 7 , 6 , 7 , 5 , 6 , 9 , 10 , 11 , 12 , 9 , 10 , 6 , 11 , 6 , 7 , 13 , 2 , 3 , 14 , 6
      Publication date (Electronic):
      Journal: Science immunology
      Publisher: American Association for the Advancement of Science (AAAS)

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          Abstract

          Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests are critically important for determining SARS-CoV-2 exposures within both individuals and populations. We validated a SARS-CoV-2 spike receptor binding domain serological test using 834 pre-pandemic samples and 31 samples from COVID-19 recovered donors. We then completed SARS-CoV-2 serological testing of 1,293 parturient women at two centers in Philadelphia from April 4 to June 3, 2020. We found 80/1,293 (6.2%) of parturient women possessed IgG and/or IgM SARS-CoV-2-specific antibodies. We found race/ethnicity differences in seroprevalence rates, with higher rates in Black/non-Hispanic and Hispanic/Latino women. Of the 72 seropositive women who also received nasopharyngeal polymerase chain reaction testing during pregnancy, 46 (64%) were positive. Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community.

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          Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

          Dawei Wang, Bo Hu, Fangfang Zhu … (2020)
          In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
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            Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records

            Huijun Chen, Juanjuan Guo, Chen Wang … (2020)
            Summary Background Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. Methods Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Evidence of intrauterine vertical transmission was assessed by testing for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. Breastmilk samples were also collected and tested from patients after the first lactation. Findings All nine patients had a caesarean section in their third trimester. Seven patients presented with a fever. Other symptoms, including cough (in four of nine patients), myalgia (in three), sore throat (in two), and malaise (in two), were also observed. Fetal distress was monitored in two cases. Five of nine patients had lymphopenia (<1·0 × 10⁹ cells per L). Three patients had increased aminotransferase concentrations. None of the patients developed severe COVID-19 pneumonia or died, as of Feb 4, 2020. Nine livebirths were recorded. No neonatal asphyxia was observed in newborn babies. All nine livebirths had a 1-min Apgar score of 8–9 and a 5-min Apgar score of 9–10. Amniotic fluid, cord blood, neonatal throat swab, and breastmilk samples from six patients were tested for SARS-CoV-2, and all samples tested negative for the virus. Interpretation The clinical characteristics of COVID-19 pneumonia in pregnant women were similar to those reported for non-pregnant adult patients who developed COVID-19 pneumonia. Findings from this small group of cases suggest that there is currently no evidence for intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia in late pregnancy. Funding Hubei Science and Technology Plan, Wuhan University Medical Development Plan.
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              Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

              Divij Mathew, Josephine Giles, Amy Baxter … (2020)
              COVID-19 is currently a global pandemic, but human immune responses to the virus remain poorly understood. We analyzed 125 COVID-19 patients, and compared recovered to healthy individuals using high dimensional cytometry. Integrated analysis of ~200 immune and ~50 clinical features revealed activation of T cell and B cell subsets in a proportion of patients. A subgroup of patients had T cell activation characteristic of acute viral infection and plasmablast responses reaching >30% of circulating B cells. However, another subgroup had lymphocyte activation comparable to uninfected subjects. Stable versus dynamic immunological signatures were identified and linked to trajectories of disease severity change. These analyses identified three “immunotypes” associated with poor clinical trajectories versus improving health. These immunotypes may have implications for the design of therapeutics and vaccines for COVID-19.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Sci Immunol
                Title: Science immunology
                Publisher: American Association for the Advancement of Science (AAAS)
                ISSN (Electronic): 2470-9468
                ISSN (Print): 2470-9468
                Publication date (Electronic): July 29 2020
                Volume: 5
                Issue: 49
                Affiliations
                [1 ] Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
                [2 ] Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
                [3 ] Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA.
                [4 ] Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
                [5 ] Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA.
                [6 ] Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
                [7 ] Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA.
                [8 ] Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
                [9 ] Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
                [10 ] Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
                [11 ] Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
                [12 ] Department of Biostatistics Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA.
                [13 ] Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA. hensley@pennmedicine.upenn.edu karen.puopolo@pennmedicine.upenn.edu.
                [14 ] Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. hensley@pennmedicine.upenn.edu karen.puopolo@pennmedicine.upenn.edu.
                Article
                Publisher Item ID: 5/49/eabd5709
                DOI: 10.1126/sciimmunol.abd5709
                PMC ID: 7594018
                PubMed ID: 32727884
                SO-VID: 87763621-521b-4627-949e-d96a0958058a
                Copyright © Copyright © 2020, American Association for the Advancement of Science.
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