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Age-related effects of vagotonic atropine on cardiovagal baroreflex gain
Author(s):
Carine C. Callegaro
,
J. Andrew Taylor
Publication date
Created:
February 2012
Publication date
(Print):
February 2012
Journal:
Neurobiology of Aging
Publisher:
Elsevier BV
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Abstract
Impaired neural transduction of barosensory vessel stretch into vagal outflow is a primary determinant of reduced cardiovagal baroreflex gain with human aging. We set out to determine whether age-related reductions in this neural component of the baroreflex might be offset by enhancing the central integration/efferent responsiveness of the neural arc. Low vagotonic doses of atropine were employed to enhance central neural outflow and peripheral sinus node effects. Baroreflex gain and its neural and mechanical components were pharmacologically assessed before and after intravenous vagotonic atropine in 16 older and 14 young healthy subjects. Vagotonic atropine increased cardiovagal baroreflex gain (∼30%) and its neural component (∼20%) in older but not young individuals. Moreover, the atropine-induced increases in integrated gain and in its neural component were inversely related to baseline levels. Thus, age-related neural deficits in the baroreflex arc appear to play a determining role in reduced cardiovagal baroreflex gain with age and the compromised neural baroreflex function can be acutely improved by a single pharmacologic intervention. Copyright © 2012. Published by Elsevier Inc.
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Author and article information
Journal
Title:
Neurobiology of Aging
Abbreviated Title:
Neurobiology of Aging
Publisher:
Elsevier BV
ISSN (Print):
01974580
Publication date Created:
February 2012
Publication date (Print):
February 2012
Volume
: 33
Issue
: 2
Pages
: 368-374
Article
DOI:
10.1016/j.neurobiolaging.2010.03.018
SO-VID:
3ec09853-b7a2-481e-b02f-1e9900962f68
Copyright ©
© 2012
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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