Journal ID (nlm-ta): Front Plant Sci
Journal ID (iso-abbrev): Front Plant Sci
Journal ID (publisher-id): Front. Plant Sci.
Title:
Frontiers in Plant Science
Publisher:
Frontiers Media S.A.
ISSN
(Electronic):
1664-462X
Publication date
(Electronic):
07
March
2023
Publication date Collection: 2023
Publication date PMC-release: 07
March
2023
Volume: 14
Electronic Location Identifier: 1146234
Affiliations
[1]
1
Division of Medical Virology, Department of Pathology, Faculty of Health Sciences,
University of Cape Town , Cape Town, South Africa
[2]
2
Wellcome Trust Centre for Infectious Disease Research in Africa, University of Cape
Town , Cape Town, South Africa
[3]
3
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences,
University of Cape Town , Cape Town, South Africa
[4]
4
Biopharming Research Unit, Department of Molecular and Cell Biology, University of
Cape Town , Cape Town, South Africa
[5]
5
International Centre for Genetic Engineering and Biotechnology, Observatory, Cape
Town , Cape Town, South Africa
[6]
6
School of Biological Sciences and Institute of Life Sciences, University of Southampton , Southampton, United Kingdom
[7]
7
Pathcare VetLab , Cape Town, South Africa
[8]
8
Electron Microscope Unit, University of Cape Town , Cape Town, South Africa
[9]
9
Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch
University Tygerberg Campus , Cape Town, South Africa
[10]
10
Department of Medical Biosciences, University of the Western Cape , Cape Town, South Africa
[11]
11
Department of Applied Genetics and Cell Biology, University of Natural Resources and
Life Sciences , Vienna, Austria
Author notes
Edited by: Qiang Chen, Arizona State University, United States
Reviewed by: Michele Bellucci, National Research Council (CNR), Italy; Hugh S. Mason,
Arizona State University, United States
This article was submitted to Plant Biotechnology, a section of the journal Frontiers
in Plant Science
Article
DOI: 10.3389/fpls.2023.1146234
PMC ID: 10028082
PubMed ID: 36959936
SO-VID: 97eabd75-8f68-48ca-b6f3-ecbcec1ae002
Copyright © Copyright © 2023 Margolin, Schäfer, Allen, Gers, Woodward, Sutherland, Blumenthal,
Meyers, Shaw, Preiser, Strasser, Crispin, Williamson, Rybicki and Chapman
License:
This is an open-access article distributed under the terms of the Creative Commons
Attribution License (CC BY). The use, distribution or reproduction in other forums
is permitted, provided the original author(s) and the copyright owner(s) are credited
and that the original publication in this journal is cited, in accordance with accepted
academic practice. No use, distribution or reproduction is permitted which does not
comply with these terms.
Page count
Figures: 5,
Tables: 0,
Equations: 0,
References: 70,
Pages: 14,
Words: 7308
Funding for the recombinant protein production described in this manuscript was supported
in part by core funding provided by the Wellcome Trust [203135/Z/16/Z]. For the purpose
of open access, the author has applied a CC BY public copyright licence to any Author
Accepted Manuscript version arising from this submission. EM was supported by scholarship
funding from CIDRI Africa. The immunogenicity and challenge work in this manuscript
was funded by the UCT Innovation Builder Fund (Project #IB20-14). Further supplementary
funding was provided by the South African Research Chairs Initiative of the Department
of Science and Technology and the National Research Foundation (grant number: 64815).
GS is supported by EDCTP2 programme (Training and Mobility Action TMA2018SF-2446)
and receives funding from the NRF, the MRC and the PRF. SARS-CoV-2 isolation and propagation
was partially supported by the South African Medical Research Council with funds received
from the Department of Science and Innovation (MS and WP), and by the Poliomyelitis
Research Foundation (WP, grant 21/81). ADS was supported by a bursary from the Poliomyelitis
Research Foundation (grant 21/45). RS was supported by the Austrian Science Fund (FWF)
Project P31920-B32. MB holds a ACSR Young Investigator Pilot Award and has received
funding from the NRF and the Oppenheimer Memorial Trust. This work was also supported
by the International AIDS Vaccine Initiative (IAVI) through grant INV- 008352/OPP1153692
funded by the Bill and Melinda Gates Foundation (MC).