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      Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study.

      Author(s): 1 , 2 , 3 , 4 , 4 , 5 , 6 , 4 , 7 , 8 , 9 , 10 , 11 , 12 , 2 , 13 , 14 , 15 , 16 , 17 , 17 , 18 , 19 , 20 , 13 , 20 , 21 , 19 , 22 , 23 , 18 , 24 , 25 , 26 , 27 , 28 , 29 , 9 , 24 , 15 , 21 , 25 , 30 , 3 , 31 , 31 , 32 , 33 , 24 , 34 , 33 , 34 , 3 , 2 , 22 , 30 , 2 , 35 , 36 , 16 , 31 , 37 , 22 , 29 , 26 , 9 , 38 , 35 , 34 , 4 , 9 , 4 , 39
      Publication date (Electronic):
      Journal: Lancet (London, England)
      Publisher: Elsevier BV

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          Abstract

          Data on patients with COVID-19 who have cancer are lacking. Here we characterise the outcomes of a cohort of patients with cancer and COVID-19 and identify potential prognostic factors for mortality and severe illness.

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          Clinical Characteristics of Coronavirus Disease 2019 in China

          Wei-jie Guan, Zheng-yi Ni, Yu Hu … (2020)
          Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. Conclusions During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)
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            Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

            Dawei Wang, Bo Hu, Fangfang Zhu … (2020)
            In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
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              SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

              Markus Hoffmann, Hannah Kleine-Weber, Simon Schroeder … (2020)
              Summary The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host cell proteases. Unravelling which cellular factors are used by SARS-CoV-2 for entry might provide insights into viral transmission and reveal therapeutic targets. Here, we demonstrate that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. Finally, we show that the sera from convalescent SARS patients cross-neutralized SARS-2-S-driven entry. Our results reveal important commonalities between SARS-CoV-2 and SARS-CoV infection and identify a potential target for antiviral intervention.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Lancet
                Title: Lancet (London, England)
                Publisher: Elsevier BV
                ISSN (Electronic): 1474-547X
                ISSN (Print): 0140-6736
                Publication date (Electronic): June 20 2020
                Volume: 395
                Issue: 10241
                Affiliations
                [1 ] Advanced Cancer Research Group, Kirkland, WA, USA.
                [2 ] Dana-Farber Cancer Institute, Boston, MA, USA.
                [3 ] Mays Cancer Center, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, USA.
                [4 ] Vanderbilt-Ingram Cancer Center at Vanderbilt University Medical Center, Nashville, TN, USA.
                [5 ] Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, MD, USA.
                [6 ] MD Anderson Cancer Center, Houston, TX, USA.
                [7 ] University of Connecticut, Farmington, CT, USA.
                [8 ] Sylvester Comprehensive Cancer Center at the University of Miami, Miami, FL, USA.
                [9 ] Fred Hutchinson Cancer Research Center, Seattle, WA, USA; University of Washington, Seattle, WA, USA.
                [10 ] Count Me In, Cambridge, MA, USA.
                [11 ] Lausanne University, Lausanne, Switzerland.
                [12 ] Advocate Aurora Health, Milwaukee, WI, USA.
                [13 ] Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, QC, Canada.
                [14 ] Mayo Clinic Cancer Center, Phoenix, AZ, USA.
                [15 ] Winship Cancer Institute of Emory University, Atlanta, GA, USA.
                [16 ] McGill University Health Centre, Montreal, QC, Canada.
                [17 ] Hospital Universitario 12 de Octubre, Madrid, Spain.
                [18 ] Stamford Hospital, Stamford, CT, USA.
                [19 ] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
                [20 ] The Warren Alpert Medical School of Brown University, Providence, RI, USA.
                [21 ] St. Elizabeth Healthcare, Edgewood, KY, USA.
                [22 ] Stanford University, Stanford, CA, USA.
                [23 ] Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
                [24 ] Cleveland Clinic, Cleveland, OH, USA.
                [25 ] Smilow Cancer Hospital at Yale New Haven, New Haven, CT, USA.
                [26 ] Mayo Clinic Cancer Center, Rochester, MN, USA.
                [27 ] Herbert Irving Comprehensive Cancer Center at Columbia University, New York, NY, USA.
                [28 ] University of Connecticut, Farmington, CT, USA; Hartford Health Care, Hartford, CT, USA.
                [29 ] University of Kansas Medical Center, Kansas City, KS, USA.
                [30 ] Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
                [31 ] The Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA.
                [32 ] School of Public Health, Brown University, Providence, RI, USA.
                [33 ] Willis-Knighton Cancer Center, Shreveport, LA, USA.
                [34 ] Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
                [35 ] Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
                [36 ] Stanley S Scott Cancer Center, LSU Health, New Orleans, LA, USA.
                [37 ] Mount Auburn Hospital, Cambridge, MA, USA.
                [38 ] Hartford Health Care, Hartford, CT, USA.
                [39 ] Vanderbilt-Ingram Cancer Center at Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: jeremy.warner@vumc.org.
                Article
                Publisher Item ID: S0140-6736(20)31187-9
                DOI: 10.1016/S0140-6736(20)31187-9
                PMC ID: 7255743
                PubMed ID: 32473681
                SO-VID: f9cce1a5-878e-49c2-987b-7efd22cd90f4
                Copyright © Copyright © 2020 Elsevier Ltd. All rights reserved.
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