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      Herbal medicine used in the treatment of cardiovascular diseases in the Rif, North of Morocco

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          Abstract

          Background: Since the dawn of time, Moroccans have used medicinal plants as a popular remedy to treat a wide range of human and cattle health issues. Nonetheless, very little research has been conducted in the past to record and disseminate indigenous ethnopharmacological knowledge adequately. This study was conducted in the Rif and attempted to identify medicinal plants used by indigenous people to treat cardiovascular problems and the ethnomedicinal knowledge linked with them.

          Methods: The ethnobotanical study was carried out in the Moroccan Rif area over 2 years, from 2016 to 2018. We questioned 520 traditional herbalists and consumers of these herbs in total. The gathered data were examined and contrasted using quantitative ethnobotanical indicators such as family importance value (FIV), the relative frequency of citation (RFC), plant part value (PPV), fidelity level (FL), and informant consensus factor (ICF).

          Results: The findings analysis revealed the presence of 33 plant species classified into 20 families, with the Poaceae dominating (7 species). Regarding disorders treated, the category of cardiac arrhythmias has the greatest ICF (0.98). The study discovered that the leaves were the most often utilized portion of the plants (PPV = 0.353) and that the most frequently used preparation was a decoction (31%).

          Conclusions: The current study’s findings revealed the presence of indigenous ethnomedicinal knowledge of medicinal plants in the Moroccan Rif to treat cardiovascular illnesses. Further phytochemical, pharmacological, and toxicological investigations should be conducted to identify novel drugs from these documented medicinal plants.

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          Most cited references61

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          Medicinal plants in Mexico: healers' consensus and cultural importance.

          Medicinal plants are an important element of indigenous medical systems in Mexico. These resources are usually regarded as part of a culture's traditional knowledge. This study examines the use of medicinal plants in four indigenous groups of Mexican Indians, Maya, Nahua, Zapotec and - for comparative purposes - Mixe. With the first three the methodology was similar, making a direct comparison of the results possible. In these studies, the relative importance of a medicinal plant within a culture is documented using a quantitative method. For the analysis the uses were grouped into 9-10 categories of indigenous uses. This report compares these data and uses the concept of informant consensus originally developed by Trotter and Logan for analysis. This indicates how homogenous the ethnobotanical information is. Generally the factor is high for gastrointestinal illnesses and for culture bound syndromes. While the species used by the 3 indigenous groups vary, the data indicate that there exist well-defined criteria specific for each culture which lead to the selection of a plant as a medicine. A large number of species are used for gastrointestinal illnesses by two or more of the indigenous groups. At least in this case, the multiple transfer of species and their uses within Mexico seems to be an important reason for the widespread use of a species. Medicinal plants in other categories (e.g. skin diseases) are usually known only in one culture and seem to be part of its traditional knowledge.
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            Global Burden of Disease and Risk Factors

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              Ethnobotanical study of medicinal plants used by people in Zegie Peninsula, Northwestern Ethiopia

              An ethnobotanical study was conducted from October 2005 to June 2006 to investigate the uses of medicinal plants by people in Zegie Peninsula, northwestern Ethiopia. Information was gathered from 200 people: 70 female and 130 males, using semistructured questionnaire. Of which, six were male local healers. The informants, except the healers, were selected randomly and no appointment was made prior to the visits. Informant consensus factor (ICF) for category of aliments and the fidelity level (FL) of the medicinal plants were determined. Sixty-seven medicinal plants used as a cure for 52 aliments were documented. They are distributed across 42 families and 64 genera. The most frequently utilized plant part was the underground part (root/rhizome/bulb) (42%). The largest number of remedies was used to treat gastrointestinal disorder and parasites infections (22.8%) followed by external injuries and parasites infections (22.1%). The administration routes are oral (51.4%), external (38.6%), nasal (7.9%), and ear (2.1%). The medicinal plants that were presumed to be effective in treating a certain category of disease, such as 'mich' and febrile diseases (0.80) had higher ICF values. This probably indicates a high incidence of these types of diseases in the region, possibly due to the poor socio-economic and sanitary conditions of this people. The medicinal plants that are widely used by the local people or used as a remedy for a specific aliment have higher FL values (Carissa spinarum, Clausena anisata, Acokanthera schimperi, Calpurnia aurea, Ficus thonningii, and Cyphostemma junceum) than those that are less popular or used to treat more than one type of aliments (Plumbago zeylanicum, Dorstenia barnimiana).
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                Author and article information

                Contributors
                Journal
                Front Pharmacol
                Front Pharmacol
                Front. Pharmacol.
                Frontiers in Pharmacology
                Frontiers Media S.A.
                1663-9812
                11 August 2022
                2022
                : 13
                : 921918
                Affiliations
                [1] 1 Interdisciplinary Research Laboratory in the Sciences , Education, and Training Indian Railways Institute Of Signal Engineering and Telecommunications (IRLSET) , Hassan First University , Settat, Morocco
                [2] 2 Agri-Food and Health Laboratory (AFHL) , Faculty of Sciences and Techniques of Settat , Hassan First University , Settat, Morocco
                [3] 3 Plant, Animal Productions and Agro-industry Laboratory , Department of Biology , Faculty of Sciences , Ibn Tofail University , Kenitra, Morocco
                Author notes

                Edited by: Colin William Wright, University of Bradford, United Kingdom

                Reviewed by: Mohamed L. Ashour, Ain Shams University, Egypt

                Riana Kleynhans, Tshwane University of Technology, South Africa

                *Correspondence: Noureddine Chaachouay, noureddine.chaachouay@ 123456uhp.ac.ma
                [ † ]

                ORCID: Noureddine Chaachouay, orcid.org/0000-0002-1925-5041

                This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology

                Article
                921918
                10.3389/fphar.2022.921918
                9404501
                36034811
                fe6839d0-c282-4f4f-98d4-caf16c5bf3d1
                Copyright © 2022 Chaachouay, Azeroual, Bencharki and Zidane.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 20 April 2022
                : 04 July 2022
                Categories
                Pharmacology
                Original Research

                Pharmacology & Pharmaceutical medicine
                cardiovascular diseases,herbal medicine,ethnobotany,ethnomedicine,medicinal and aromatic plant

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