Recent advances in chemical dearomatization of nonactivated arenes

Abstract

A comprehensive review of recent developments and applications of dearomatization of simple, nonactivated aromatic compounds.

Abstract

Dearomatization reactions provide a synthetic connection between readily available, simple aromatic starting materials and more saturated intermediates of greater molecular complexity and synthetic utility. The last decade has witnessed a steady increase in the development of dearomative methods, providing new synthetic approaches to high-value building blocks and natural products. This review highlights advances both in the area of dearomatization methodologies for the most chemically inert arenes and in synthetic applications of such strategies.