Short-term acute bright light exposure induces a prolonged anxiogenic effect in mice via a retinal ipRGC-CeA circuit

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Abstract

Light modulates mood through various retina-brain pathways. We showed that mice treated with short-term acute bright light exposure displayed anxiety-related phenotypes in a prolonged manner even after the termination of the exposure. Such a postexposure anxiogenic effect depended upon melanopsin-based intrinsically photosensitive retinal ganglion cell (ipRGC) activities rather than rod/cone photoreceptor inputs. Chemogenetic manipulation of specific central nuclei demonstrated that the ipRGC–central amygdala (CeA) visual circuit played a key role in this effect. The corticosterone system was likely to be involved in this effect, as evidenced by enhanced expression of the glucocorticoid receptor (GR) protein in the CeA and the bed nucleus of the stria terminalis and by the absence of this effect in animals treated with the GR antagonist. Together, our findings reveal a non-image forming visual circuit specifically designed for “the delayed” extinction of anxiety against potential threats, thus conferring a survival advantage.

Abstract

Intrinsically photosensitive ganglion cells in the retina activated by bright light are involved in anxiety.

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Most cited references 77

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Phototransduction by retinal ganglion cells that set the circadian clock.

David Berson, Felice A Dunn, Motoharu Takao (2002)

Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker-the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when all synaptic input from rods and cones was blocked. The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system.

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Record: found
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Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN.

Dennis M Dacey, Hsi-Wen Liao, Beth B Peterson … (2005)

Human vision starts with the activation of rod photoreceptors in dim light and short (S)-, medium (M)-, and long (L)- wavelength-sensitive cone photoreceptors in daylight. Recently a parallel, non-rod, non-cone photoreceptive pathway, arising from a population of retinal ganglion cells, was discovered in nocturnal rodents. These ganglion cells express the putative photopigment melanopsin and by signalling gross changes in light intensity serve the subconscious, 'non-image-forming' functions of circadian photoentrainment and pupil constriction. Here we show an anatomically distinct population of 'giant', melanopsin-expressing ganglion cells in the primate retina that, in addition to being intrinsically photosensitive, are strongly activated by rods and cones, and display a rare, S-Off, (L + M)-On type of colour-opponent receptive field. The intrinsic, rod and (L + M) cone-derived light responses combine in these giant cells to signal irradiance over the full dynamic range of human vision. In accordance with cone-based colour opponency, the giant cells project to the lateral geniculate nucleus, the thalamic relay to primary visual cortex. Thus, in the diurnal trichromatic primate, 'non-image-forming' and conventional 'image-forming' retinal pathways are merged, and the melanopsin-based signal might contribute to conscious visual perception.

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The role of the amygdala in fear and anxiety.

M DAVIS (1992)

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Author and article information

Contributors

Ge Wang:

ORCID: https://orcid.org/0000-0002-7198-134X

Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: SoftwareRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing

Yun-Feng Liu: Role: Formal analysisRole: InvestigationRole: Methodology

Zhe Yang: Role: InvestigationRole: Writing - review & editing

Chen-Xi Yu:

ORCID: https://orcid.org/0000-0003-3647-6310

Role: InvestigationRole: Resources

Qiuping Tong: Role: Formal analysisRole: InvestigationRole: Validation

Yu-Long Tang:

ORCID: https://orcid.org/0000-0001-8047-6751

Role: InvestigationRole: MethodologyRole: ResourcesRole: ValidationRole: Writing - review & editing

Yu-Qi Shao: Role: Investigation

Li-Qin Wang: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review & editing

Xun Xu: Role: Formal analysisRole: Investigation

Hong Cao:

ORCID: https://orcid.org/0000-0001-5048-3379

Role: Formal analysis

Yu-Qiu Zhang:

ORCID: https://orcid.org/0000-0001-6623-9629

Role: Formal analysisRole: Methodology

Yong-Mei Zhong:

ORCID: https://orcid.org/0000-0002-3382-2655

Role: Formal analysisRole: Funding acquisitionRole: Project administrationRole: VisualizationRole: Writing - review & editing

Shi-Jun Weng:

ORCID: https://orcid.org/0000-0001-6550-892X

Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: Project administrationRole: ValidationRole: Writing - original draftRole: Writing - review & editing

Xiong-Li Yang:

ORCID: https://orcid.org/0000-0003-2128-9950

Role: ConceptualizationRole: Funding acquisitionRole: SupervisionRole: ValidationRole: Writing - review & editing

Journal

Journal ID (nlm-ta): Sci Adv

Journal ID (iso-abbrev): Sci Adv

Journal ID (publisher-id): sciadv

Journal ID (hwp): advances

Title: Science Advances

Publisher: American Association for the Advancement of Science

ISSN (Electronic): 2375-2548

Publication date Collection: March 2023

Publication date (Electronic, pub): 22 March 2023

Volume: 9

Issue: 12

Electronic Location Identifier: eadf4651

Affiliations

[ ¹ ]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.

[ ² ]Department of Ophthalmology, Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.

Author notes

[* ]Corresponding author. Email: xlyang@ 123456fudan.edu.cn (X.-L.Y.); sjweng@ 123456fudan.edu.cn (S.-J.W.)

Author information

Ge Wang https://orcid.org/0000-0002-7198-134X

Chen-Xi Yu https://orcid.org/0000-0003-3647-6310

Yu-Long Tang https://orcid.org/0000-0001-8047-6751

Hong Cao https://orcid.org/0000-0001-5048-3379

Yu-Qiu Zhang https://orcid.org/0000-0001-6623-9629

Yong-Mei Zhong https://orcid.org/0000-0002-3382-2655

Shi-Jun Weng https://orcid.org/0000-0001-6550-892X

Xiong-Li Yang https://orcid.org/0000-0003-2128-9950

Article

Publisher ID: adf4651

DOI: 10.1126/sciadv.adf4651

PMC ID: 10032603

PubMed ID: 36947616

SO-VID: f3a0121c-c8a6-4e77-87b7-8948f3b46583

Copyright © Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.