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      Adult vaccination as part of a healthy lifestyle: moving from medical intervention to health promotion

      review-article
      a , b , c
      Annals of Medicine
      Taylor & Francis
      Ageing, frailty, immunosenescence, vaccination, healthy ageing, healthy lifestyle

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          As the global population ages, there is concern about the effect of an increased proportion of older individuals on the economic sustainability of healthcare systems and the social effects of an older society. Health authorities and advocacy groups in countries at the forefront of this trend are now developing strategies to ameliorate the social and financial effects of an ageing population. There is broad agreement that for both society and for the individuals, it is important to ensure that increasing lifespans are matched with increased “healthspans” – the number of years spent in good health. There is also growing consensus that vaccination is one of the tools that can play an important role in improving adult health – though currently vaccination coverage is often poor. This review focuses on two issues that consistently appear to be associated with under-vaccination: the low awareness of risk (and potential consequences) for vaccine-preventable diseases and a poor understanding of the value of improved vaccination coverage for adults. We suggest that understanding of vaccination as a health-promoting activity, rather than a medical intervention designed to prevent the spread of a specific pathogen – is a crucial step to improve vaccination uptake among adults (see Supplementary video abstract).

          Key messages
          • As populations age globally, we are seeing an increasing burden of vaccine-preventable disease in adults.

          • Adult vaccination against some common diseases has been shown to dramatically improve health and quality of life for older people.

          • Despite the attested benefits, vaccination coverage is almost always poor in adults, even in countries where access is free at point of care.

          • In this article, we discuss what appears to a neglected issue in adult vaccination, that of personal autonomy. We argue that adult vaccination will only be successful if it respects individual autonomy and that this requires treating the choice to vaccinate as a public health issue akin to smoking cessation, exercise and healthy diet.

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          Most cited references107

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          Inflammaging: a new immune–metabolic viewpoint for age-related diseases

          Ageing and age-related diseases share some basic mechanistic pillars that largely converge on inflammation. During ageing, chronic, sterile, low-grade inflammation - called inflammaging - develops, which contributes to the pathogenesis of age-related diseases. From an evolutionary perspective, a variety of stimuli sustain inflammaging, including pathogens (non-self), endogenous cell debris and misplaced molecules (self) and nutrients and gut microbiota (quasi-self). A limited number of receptors, whose degeneracy allows them to recognize many signals and to activate the innate immune responses, sense these stimuli. In this situation, metaflammation (the metabolic inflammation accompanying metabolic diseases) is thought to be the form of chronic inflammation that is driven by nutrient excess or overnutrition; metaflammation is characterized by the same mechanisms underpinning inflammaging. The gut microbiota has a central role in both metaflammation and inflammaging owing to its ability to release inflammatory products, contribute to circadian rhythms and crosstalk with other organs and systems. We argue that chronic diseases are not only the result of ageing and inflammaging; these diseases also accelerate the ageing process and can be considered a manifestation of accelerated ageing. Finally, we propose the use of new biomarkers (DNA methylation, glycomics, metabolomics and lipidomics) that are capable of assessing biological versus chronological age in metabolic diseases.
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            • Article: not found

            Geroscience: linking aging to chronic disease.

            Mammalian aging can be delayed with genetic, dietary, and pharmacologic approaches. Given that the elderly population is dramatically increasing and that aging is the greatest risk factor for a majority of chronic diseases driving both morbidity and mortality, it is critical to expand geroscience research directed at extending human healthspan.
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              • Article: not found

              The World report on ageing and health: a policy framework for healthy ageing.

              Although populations around the world are rapidly ageing, evidence that increasing longevity is being accompanied by an extended period of good health is scarce. A coherent and focused public health response that spans multiple sectors and stakeholders is urgently needed. To guide this global response, WHO has released the first World report on ageing and health, reviewing current knowledge and gaps and providing a public health framework for action. The report is built around a redefinition of healthy ageing that centres on the notion of functional ability: the combination of the intrinsic capacity of the individual, relevant environmental characteristics, and the interactions between the individual and these characteristics. This Health Policy highlights key findings and recommendations from the report.
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                Author and article information

                Journal
                Ann Med
                Ann Med
                Annals of Medicine
                Taylor & Francis
                0785-3890
                1365-2060
                26 April 2019
                2019
                : 51
                : 2
                : 128-140
                Affiliations
                [a ]GSK, Global Medical Affairs , Wavre, Belgium;
                [b ]GSK, Vaccine Research & Development Discovery Performance , Siena, Italy;
                [c ]CNR, Institute of Neuroscience - Aging Branch , Padua, Italy
                Author notes
                CONTACT T. Mark Doherty mark.x.doherty@ 123456gsk.com GSK, Global Medical Affairs , 20 Avenue Fleming, Parc de la Noire Epine, B-1300Wavre, Belgium

                Supplemental data for this article can be accessed here .

                Author information
                https://orcid.org/0000-0003-3009-7969
                Article
                1588470
                10.1080/07853890.2019.1588470
                7857442
                31025882
                edc4f33c-86c0-4935-897b-426bdd18140e
                © 2019 GSK Group of companies. Published by Informa UK Limited, trading as Taylor & Francis Group.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Page count
                Figures: 0, Tables: 1, Pages: 13, Words: 10314
                Categories
                Review Article
                Review Article

                Medicine
                ageing,frailty,immunosenescence,vaccination,healthy ageing,healthy lifestyle
                Medicine
                ageing, frailty, immunosenescence, vaccination, healthy ageing, healthy lifestyle

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