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      Applications of nanoparticle systems in drug delivery technology

      review-article
      Author(s): a , * , b , *
      Publication date (Electronic):
      Journal: Saudi Pharmaceutical Journal : SPJ
      Publisher: Elsevier

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          Abstract

          The development of nanoparticle-based drug formulations has yielded the opportunities to address and treat challenging diseases. Nanoparticles vary in size but are generally ranging from 100 to 500 nm. Through the manipulation of size, surface characteristics and material used, the nanoparticles can be developed into smart systems, encasing therapeutic and imaging agents as well as bearing stealth property. Further, these systems can deliver drug to specific tissues and provide controlled release therapy. This targeted and sustained drug delivery decreases the drug related toxicity and increase patient’s compliance with less frequent dosing. Nanotechnology has proven beneficial in the treatment of cancer, AIDS and many other disease, also providing advancement in diagnostic testing.

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          Most cited references78

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          Nanoparticle-based targeted drug delivery.

          Rajesh Singh, James W. Lillard (2009)
          Nanotechnology could be defined as the technology that has allowed for the control, manipulation, study, and manufacture of structures and devices in the "nanometer" size range. These nano-sized objects, e.g., "nanoparticles", take on novel properties and functions that differ markedly from those seen from items made of identical materials. The small size, customized surface, improved solubility, and multi-functionality of nanoparticles will continue to open many doors and create new biomedical applications. Indeed, the novel properties of nanoparticles offer the ability to interact with complex cellular functions in new ways. This rapidly growing field requires cross-disciplinary research and provides opportunities to design and develop multifunctional devices that can target, diagnose, and treat devastating diseases such as cancer. This article presents an overview of nanotechnology for the biologist and discusses the attributes of our novel XPclad((c)) nanoparticle formulation that has shown efficacy in treating solid tumors, single dose vaccination, and oral delivery of therapeutic proteins.
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            New Developments in Liposomal Drug Delivery.

            Bhushan S Pattni, Vladimir Chupin, Vladimir P. Torchilin (2015)
            Article 0 comments Cited 365 times – based on 0 reviews     Review now
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              Bioavailability of resveratrol.

              Thomas Walle (2011)
              This paper reviews our current understanding of the absorption, bioavailability, and metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in humans is about 75% and is thought to occur mainly by transepithelial diffusion. Extensive metabolism in the intestine and liver results in an oral bioavailability considerably less than 1%. Dose escalation and repeated dose administration of resveratrol does not appear to alter this significantly. Metabolic studies, both in plasma and in urine, have revealed major metabolites to be glucuronides and sulfates of resveratrol. However, reduced dihydroresveratrol conjugates, in addition to highly polar unknown products, may account for as much as 50% of an oral resveratrol dose. Although major sites of metabolism include the intestine and liver (as expected), colonic bacterial metabolism may be more important than previously thought. Deconjugation enzymes such as β-glucuronidase and sulfatase, as well as specific tissue accumulation of resveratrol, may enhance resveratrol efficacy at target sites. Resveratrol analogs, such as methylated derivatives with improved bioavailability, may be important in future research. © 2011 New York Academy of Sciences.
              Article 0 comments Cited 281 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Syed A.A. Rizvi
                Ayman M. Saleh
                Journal
                Journal ID (nlm-ta): Saudi Pharm J
                Journal ID (iso-abbrev): Saudi Pharm J
                Title: Saudi Pharmaceutical Journal : SPJ
                Publisher: Elsevier
                ISSN (Print): 1319-0164
                ISSN (Electronic): 2213-7475
                Publication date PMC-release: 25 October 2017
                Publication date (Print): January 2018
                Publication date (Electronic): 25 October 2017
                Volume: 26
                Issue: 1
                Pages: 64-70
                Affiliations
                [a ]Department of Pharmaceutical Sciences, College of Pharmacy, Health Professions Division, Nova Southeastern University, 3200 South University Drive, Fort Lauderdale, FL 33328, USA
                [b ]Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center (KAIMRC), King Abdulaziz Medical City, National Guard Health Affairs, Mail Code 6610, P. O. Box 9515, Jeddah 21423, Saudi Arabia
                Author notes
                Article
                Publisher ID: S1319-0164(17)30179-2
                DOI: 10.1016/j.jsps.2017.10.012
                PMC ID: 5783816
                PubMed ID: 29379334
                SO-VID: e6b20d35-0f01-45b2-a118-ebeb6e1f6f77
                Copyright © © 2017 The Authors
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 13 June 2017
                Date accepted : 22 October 2017
                Categories
                Subject: Article

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