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Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy
Author(s):
Morteza Mahmoudi
,
Shilpa Sant
,
Ben Wang
,
Sophie Laurent
,
Tapas Sen
Publication date
Created:
January 2011
Publication date
(Print):
January 2011
Journal:
Advanced Drug Delivery Reviews
Publisher:
Elsevier BV
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PubMed
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Abstract
At present, nanoparticles are used for various biomedical applications where they facilitate laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the use of nanoparticles is attracting increasing attention due to their unique capabilities and their negligible side effects not only in cancer therapy but also in the treatment of other ailments. Among all types of nanoparticles, biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) with proper surface architecture and conjugated targeting ligands/proteins have attracted a great deal of attention for drug delivery applications. This review covers recent advances in the development of SPIONs together with their possibilities and limitations from fabrication to application in drug delivery. In addition, the state-of-the-art synthetic routes and surface modification of desired SPIONs for drug delivery purposes are described. Copyright © 2010 Elsevier B.V. All rights reserved.
Related collections
Electrospinning for biomedical applications
Author and article information
Journal
Title:
Advanced Drug Delivery Reviews
Abbreviated Title:
Advanced Drug Delivery Reviews
Publisher:
Elsevier BV
ISSN (Print):
0169409X
Publication date Created:
January 2011
Publication date (Print):
January 2011
Volume
: 63
Issue
: 1-2
Pages
: 24-46
Article
DOI:
10.1016/j.addr.2010.05.006
PubMed ID:
20685224
SO-VID:
e64c5642-121f-4039-962d-decf5c4f7599
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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