<p class="first" id="d9012098e134">Polymorphisms of vitamin D receptors (VDRs), ApaI,
BsmI, FokI, and TaqI might affect
susceptibility to tuberculosis (TB). In this systematic review and meta-analysis,
all published articles which investigated the effects of these polymorphisms on the
risk of TB in the Iranian population were retrieved. PubMed and Scopus were searched
with no date or language restrictions. In this meta-analysis, the Comprehensive Meta-Analysis
(CMA) version 2.0 and random effects model were applied. The association of polymorphisms
with TB risk was assessed by measuring the odds ratio (ORs) at 95% CI. Heterogeneity
was investigated based on Cochran Q-test and I2-index statistics. The significance
level was set at 0.05. Also, Egger's regression intercept was determined to measure
publication bias. A total of six articles on Iranian populations were included. TaqI
(5/6 included studies) showed a significant association with the increased risk of
TB based on ORs (allele comparison: 1.57 (1.0, 2.3), p-value: 0.02; additive model
of tt/TT: 1.57 (0.9, 2.5), p-value: 0.05; recessive model (tt/Tt + TT): 1.99 (1.2,
3.2), p-value: 0.00; dominant model (tt + Tt/TT): 1.98 (1.1, 3.5), p-value: 0.01).
BsmI showed a significant positive effect on TB risk only in its dominant genotype
(bb + bB/BB) (1.44 (1.0, 1.9); p-value: 0.02). FokI and ApaI did not show any significant
effects on TB development in Iranian populations. Findings showed the significant
effect of TaqI polymorphism in all genetic models and the dominant model of BsmI on
the increased risk of TB. However, the effects of TaqI and BsmI should be further
investigated in a larger sample size.
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