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      Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease

      research-article
      Author(s): 1 , 2 , 3 , 1 , 1 , 1 ,
      Publication date (Electronic):
      Journal: Biological Research
      Publisher: BioMed Central
      Keywords: Astilbin, ROS, Nrf2, Psoriasis

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          Abstract

          Background

          Psoriasis is a common and intractable skin disease affecting the physical and mental health of patients. The accumulation of ROS is involved in the pathogenesis of psoriasis and antioxidants are believed to be therapeutic. This study aimed to investigate the therapeutic efficacy of astilbin on ROS accumulation in psoriasis.

          Results

          The study showed that 50 μg/ml astilbin could inhibit the growth and reduce the accumulation of ROS in HaCaT cells stimulated by IL-17 and TNF-α. Astilbin could elevate the Nrf2 accumulation in the nuclei, eventually leading to the transcriptional activation of various antioxidant proteins and reducing the expression of VEGF.

          Conclusions

          Our results collectively suggest that astilbin could induce Nrf2 nucleus translocation, which is contribute to reduce the ROS accumulation and VEGF expression, and inhibit the proliferation of HaCaT cells.

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          Most cited references35

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          Pathogenesis and therapy of psoriasis.

          Michelle Lowes, Anne M Bowcock, James G. Krueger (2007)
          Psoriasis is one of the most common human skin diseases and is considered to have key genetic underpinnings. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells, dendritic cells and various immune-related cytokines and chemokines implicated in pathogenesis. The newest therapies for psoriasis target its immune components and may predict potential treatments for other inflammatory human diseases.
          Article 0 comments Cited 419 times – based on 0 reviews     Review now
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            Psoriasis.

            Paola Di Meglio, Federica Villanova, Frank O. Nestle (2014)
            Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated many of the pathogenic mechanisms underlying disease and paved the way to effective targeted therapies. Here, we review this progress and identify future directions of study that are supported by a more integrative research approach and aim at further improving the patients' life.
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              Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.

              Rikard Holmdahl, Outi Sareila, Lina Olsson … (2016)
              The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced reactive oxygen species (ROS) is based on a genetic search for the major genes controlling autoimmune inflammatory disorders. Surprisingly, the disease-promoting allele determined a lower ROS response and was therefore in complete contrast to the prevailing dogma. Once cloned, it opened the possibility to dissect this complex field from a new angle and with the possibilities to study the role of ROS in vivo. We found that NCF1 and NADPH oxidase 2 (NOX2) complex-derived ROS is an important regulator of several chronic inflammatory disorders by using models for rheumatoid arthritis, multiple sclerosis, psoriasis and psoriasis arthritis, gout, and lupus. ROS could therefore affect many different types of diseases and the common denominator seems to be that ROS regulate macrophages, which prevents inflammation from going chronic. The role of ROS is currently changing from being seen as toxic agents that will promote inflammation toward a more complex view with ROS as crucial regulators of immune and inflammatory pathways.
              Article 0 comments Cited 51 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Wuyuntana Wang: wytn3890@sohu.com
                Yuhai: 380282205@qq.com
                Huan Wang: wanghuan8217776@163.com
                Chasuna: 949443631@qq.com
                Bagenna: bagenna@126.com
                Journal
                Journal ID (nlm-ta): Biol Res
                Journal ID (iso-abbrev): Biol. Res
                Title: Biological Research
                Publisher: BioMed Central (London )
                ISSN (Print): 0716-9760
                ISSN (Electronic): 0717-6287
                Publication date (Electronic): 6 September 2019
                Publication date PMC-release: 6 September 2019
                Publication date Collection: 2019
                Volume: 52
                Electronic Location Identifier: 49
                Affiliations
                [1 ]ISNI 0000 0000 8547 6673, GRID grid.411647.1, Department of Mongolian Pharmacy, School of Mongol Medicine, , Inner Mongolia University for Nationalities, ; 536 West of Huolinhe Street, Tongliao, 028000 Inner Mongolia People’s Republic of China
                [2 ]ISNI 0000 0000 8547 6673, GRID grid.411647.1, Department of Dermatology, , Affiliated Hospital of Inner Mongolia University for Nationalities, ; Tongliao, Inner Mongolia People’s Republic of China
                [3 ]ISNI 0000 0000 8547 6673, GRID grid.411647.1, Library of Inner, Mongolia University for Nationalities, ; Tongliao, Inner Mongolia People’s Republic of China
                Article
                Publisher ID: 255
                DOI: 10.1186/s40659-019-0255-2
                PMC ID: 6729080
                PubMed ID: 31492195
                SO-VID: df2deee5-394c-4bea-b4e5-8d37b494bb2e
                Copyright © © The Author(s) 2019
                License:

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                Date received : 11 February 2019
                Date accepted : 13 August 2019
                Funding
                Funded by: Science Research Project of Inner Mongolia Higher Educational System
                Award ID: NJZZ18155
                Award Recipient :
                Funded by: Scientific Research Foundation of Affiliated Hospital of Inner Mongolia University for Nationalities
                Award ID: 2017QDJJ08
                Award Recipient :
                Categories
                Subject: Research Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2019

                Keywords: astilbin,ros,nrf2,psoriasis
                Data availability:
                Keywords: astilbin, ros, nrf2, psoriasis

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