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      Cannabis Use and the Risk for Psychosis and Affective Disorders

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          Most cited references129

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          The molecular logic of endocannabinoid signalling.

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            The endocannabinoid system and the brain.

            The psychoactive constituent in cannabis, Δ(9)-tetrahydrocannabinol (THC), was isolated in the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous cannabinoids (anandamide and 2-arachidonoyl glycerol) were identified only 20 to 25 years later. The cannabinoid system affects both central nervous system (CNS) and peripheral processes. In this review, we have tried to summarize research--with an emphasis on recent publications--on the actions of the endocannabinoid system on anxiety, depression, neurogenesis, reward, cognition, learning, and memory. The effects are at times biphasic--lower doses causing effects opposite to those seen at high doses. Recently, numerous endocannabinoid-like compounds have been identified in the brain. Only a few have been investigated for their CNS activity, and future investigations on their action may throw light on a wide spectrum of brain functions.
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              Prevalence of Marijuana Use Disorders in the United States Between 2001-2002 and 2012-2013.

              Laws and attitudes toward marijuana in the United States are becoming more permissive but little is known about whether the prevalence rates of marijuana use and marijuana use disorders have changed in the 21st century.
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                Author and article information

                Journal
                Journal of Dual Diagnosis
                Journal of Dual Diagnosis
                Informa UK Limited
                1550-4263
                1550-4271
                January 02 2020
                October 24 2019
                January 02 2020
                : 16
                : 1
                : 22-42
                Affiliations
                [1 ] Institute of Psychiatry, Psychology, and Neuroscience, King’s College, London, UK;
                [2 ] Department of Biomedicine, Neurosciences, and Advanced Diagnostic, University of Palermo, Palermo, Italy;
                [3 ] South London and Maudsley NHS Trust Biomedical Research Centre, London, UK
                Article
                10.1080/15504263.2019.1674991
                31647377
                de53b0f2-3f96-428d-ba39-2982703f16dd
                © 2020
                History

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