Frequency of radiation-induced malignancies post-adjuvant radiotherapy for breast cancer in patients with Li-Fraumeni syndrome.

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Abstract

Women with Li-Fraumeni syndrome (LFS), a cancer predisposition syndrome caused by germline mutations in TP53, have an over 50% risk of developing breast cancer by age 70. Patients with LFS are at risk for radiation-induced malignancies; however, only small case series have prior investigated radiation risks in the treatment of breast cancer. We therefore aimed to investigate the risk of malignancy in breast cancer patients with LFS following adjuvant radiotherapy.

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Journal

Journal ID (iso-abbrev): Breast Cancer Res Treat

Title: Breast cancer research and treatment

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1573-7217

ISSN (Print): 0167-6806

Publication date (Electronic): May 2020

Volume: 181

Issue: 1

Affiliations

[1 ] Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

[2 ] Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

[3 ] Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

[4 ] Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA.

[5 ] Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

[6 ] Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

[7 ] Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.

[8 ] Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

[9 ] Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. kara.maxwell@pennmedicine.upenn.edu.

[10 ] Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, 19104, USA. kara.maxwell@pennmedicine.upenn.edu.

[11 ] Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. kara.maxwell@pennmedicine.upenn.edu.

Article

Publisher Item ID: 10.1007/s10549-020-05612-7 Mid ID: NIHMS1581812

DOI: 10.1007/s10549-020-05612-7

PMC ID: 7285877

PubMed ID: 32246378

SO-VID: dce212e0-1c24-453d-99d4-dd9768cf8b1a

History

Keywords: Radiation-induced malignancy,Radiotherapy,Breast cancer,Li-Fraumeni syndrome

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Keywords: Radiation-induced malignancy, Radiotherapy, Breast cancer, Li-Fraumeni syndrome

Frequency of radiation-induced malignancies post-adjuvant radiotherapy for breast cancer in patients with Li-Fraumeni syndrome.

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Karger: Oncology

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