Contributors
Dany Spaggiari: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original
draft
Vincent Desfontaine: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
VisualizationRole: Writing – review & editing
Sandra Cruchon: Role: Formal analysis
Sylvie Guinchard: Role: Formal analysis
Anthony Vocat: Role: Writing – review & editing
Emilyne Blattes: Role: Project administrationRole: ResourcesRole: ValidationRole: Writing – review
& editing
Jeff Pitteloud: Role: Investigation
Lorenzo Ciullini:
ORCID: http://orcid.org/0000-0003-4429-7179
Role: Investigation
Carine Bardinet: Role: InvestigationRole: Project administration
Anton Ivanyuk: Role: Investigation
Vadim Makarov: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Olga Ryabova: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Thierry Buclin: Role: Funding acquisitionRole: InvestigationRole: Project administrationRole: SupervisionRole:
Writing – review & editing
Stewart T. Cole: Role: Funding acquisitionRole: InvestigationRole: Project administrationRole: ResourcesRole:
Writing – review & editing
Laurent A. Decosterd:
ORCID: http://orcid.org/0000-0002-9840-1325
Role: Funding acquisitionRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing – review & editing
Sonja Hess: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
31
May
2019
Publication date Collection: 2019
Volume: 14
Issue: 5
Electronic Location Identifier: e0217139
Affiliations
[1
]
Laboratory & Service of Clinical Pharmacology, Department of Laboratories, University
Hospital of Lausanne and University of Lausanne, Lausanne, Switzerland
[2
]
Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland
[3
]
Innovative Medicines for Tuberculosis (IM4TB), Lausanne, Switzerland
[4
]
Federal Research Center “Fundamentals of Biotechnology RAS”, Moscow, Russia
Author notes
Competing Interests: The authors have declared that no competing interests exist.
[¤a]
Current address: Debiopharm International SA, Lausanne, Switzerland
[¤b]
Current address: Pasteur Institute, Paris, France
Author information
Article
Publisher ID:
PONE-D-18-27336
DOI: 10.1371/journal.pone.0217139
PMC ID: 6544242
PubMed ID: 31150423
SO-VID: d06367e5-9baf-4c63-a3ee-ab518a4f9b9d
Copyright © © 2019 Spaggiari et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 20
September
2018
Date
accepted
: 7
May
2019
Page count
Figures: 4,
Tables: 2,
Pages: 22
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100000865, Bill and Melinda Gates Foundation;
Award ID: OPP1164837
Award Recipient
:
Emilyne Blattes
Funded by: Swiss National Science Foundation
Award ID: 324730-165956
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9840-1325
Laurent A. Decosterd
Funded by: Swiss National Science Foundation
Award ID: 326000-121314/1
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9840-1325
Laurent A. Decosterd
This research program is supported by the Bill and Melinda Gates Foundation (grant
OPP1164837) through the study sponsor im4TB (EB). Support for this work and part of
the salaries of DS were also provided by a grant from the Swiss National Science Foundation
(SNF) N° SNF 324730-165956 to LAD. This analytical project performed at the Laboratory
of Clinical Pharmacology also benefits from the REQUIP grant SNF No 326000-121314/1
to LAD and from a donation of the Loterie Romande for the acquisition of LC-MS/MS
instrumentation. The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Pharmacokinetics
Subject:
Drug Metabolism
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolites
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolic Processes
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Actinobacteria
Subject:
Mycobacterium Tuberculosis
Subject:
Research and Analysis Methods
Subject:
Spectrum Analysis Techniques
Subject:
Inductively Coupled Plasma Emission Spectroscopy
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Pharmacokinetics
Custom metadata