Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits.

Ilmarinen, Tanja; Thieltges, Fabian; Hongisto, Heidi; Juuti-Uusitalo, Kati; Koistinen, Arto P; Kaarniranta, Kai; Brinken, Ralf; Braun, Norbert; Holz, Frank G; Skottman, Heli; Stanzel, Boris V

doi:10.1111/aos.14004

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Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits.

Author(s): Tanja Ilmarinen ¹ , Fabian Thieltges ² , Heidi Hongisto ¹ ^, ³ , Kati Juuti-Uusitalo ¹ , Arto Koistinen ⁴ , Kai Kaarniranta ³ ^, ⁵ , Ralf Brinken ² , Norbert Braun ⁶ , Frank G Holz ² , Heli Skottman ¹ , Boris V Stanzel ²

Publication date (Electronic): Aug 2019

Journal: Acta ophthalmologica

Publisher: Wiley

Keywords: RPE transplantation, age-related macular degeneration, cell therapy, pluripotent stem cell, xeno-free

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Abstract

To study immunogenic properties of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) and to evaluate subretinal xenotransplantation of hESC-RPE on porous polyethylene terephthalate (PET) in rabbits.

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Journal ID (iso-abbrev): Acta Ophthalmol

Title: Acta ophthalmologica

Publisher: Wiley

ISSN (Electronic): 1755-3768

ISSN (Print): 1755-375X

Publication date (Electronic): Aug 2019

Volume: 97

Issue: 5

Affiliations

[1 ] BioMediTech Institute, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

[2 ] Department of Ophthalmology, University of Bonn, Bonn, Germany.

[3 ] Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

[4 ] SIBS Labs, University of Eastern Finland, Kuopio, Finland.

[5 ] Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland.

[6 ] Geuder AG, Heidelberg, Germany.

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DOI: 10.1111/aos.14004

PubMed ID: 30593729

SO-VID: cd43a57e-8f68-45f5-aaf6-c7b46e41b5e6

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Keywords: pluripotent stem cell,RPE transplantation,age-related macular degeneration,cell therapy,xeno-free

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Keywords: pluripotent stem cell, RPE transplantation, age-related macular degeneration, cell therapy, xeno-free

Survival and functionality of xeno-free human embryonic stem cell-derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits.

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Karger: Ophthalmology

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