Cancer metastasis: building a framework.

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Abstract

Metastasis occurs when genetically unstable cancer cells adapt to a tissue microenvironment that is distant from the primary tumor. This process involves both the selection of traits that are advantageous to cancer cells and the concomitant recruitment of traits in the tumor stroma that accommodate invasion by metastatic cells. Recent conceptual and technological advances promote our understanding of the origins and nature of cancer metastasis.

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Journal

Journal ID (iso-abbrev): Cell

Title: Cell

Publisher: Elsevier BV

ISSN: 0092-8674

ISSN (Print): 0092-8674

Publication date (Electronic): Nov 17 2006

Volume: 127

Issue: 4

Affiliations

[1 ] Cancer Biology and Genetics Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Article

Publisher Item ID: S0092-8674(06)01414-0

DOI: 10.1016/j.cell.2006.11.001

PubMed ID: 17110329

SO-VID: c9bc2f34-c96e-4201-95c6-2e9d69d072ad

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