[1
]Department of Neurology & Neurosurgery, McConnell Brain Imaging Centre, Montreal Neurological
Institute , Montreal, Quebec, Canada H3A 2B4
[2
]Ludmer Centre for NeuroInformatics and Mental Health , Montreal, Quebec, Canada H3A 2B4
[3
]Department of Radiology and Hotchkiss Brain institute, University of Calgary , Calgary, Alberta, Canada T2N 4N1
[4
]UC San Francisco , California, USA
[5
]UC San Diego , California, USA
[6
]Mayo Clinic , Rochester, New York, USA
[7
]UC Berkeley , California, USA
[8
]UPenn , Philadelphia, Pennsylvania, USA
[9
]USC , Los Angeles, California, USA
[10
]UC Davis , California, USA
[11
]Brigham and Women's Hospital/Harvard Medical School , Boston, Massachusetts, USA
[12
]Indiana University , Bloomington, Indiana, USA
[13
]Washington University St Louis , Missouri, USA
[14
]Prevent Alzheimer's Disease 2020 , Rockville, Maryland, USA
[15
]Siemens, Munich, Germany
[16
]University of Pittsburg , Pennsylvania, USA
[17
]Cornell University , Ithaca, New York, USA
[18
]Albert Einstein College of Medicine of Yeshiva University , Bronx, New York, USA
[19
]AD Drug Discovery Foundation , New York City, New York, USA
[20
]Acumen Pharmaceuticals , Livermore, California, USA
[21
]Northwestern University , Evanston and Chicago, Illinois, USA
[22
]National Institute of Mental Health , Rockville, Maryland, USA
[23
]Brown University , Providence, Rhode Island, USA
[24
]Eli Lilly , Indianapolis, Indiana, USA
[25
]University of Washington , Seattle, Washington, USA
[26
]University of London , London, England
[27
]UCLA , Los Angeles, California, USA
[28
]University of Michigan , Ann Arbor, Michigan, USA
[29
]University of Utah , Salt Lake, Utah, USA
[30
]Banner Alzheimer's Institute , Phoenix, Arizona, USA
[31
]UC Irvine , Irvine, California, USA
[32
]National Institute on Aging , Bethesda, Maryland, USA
[33
]Johns Hopkins University , Baltimore, Maryland, USA
[34
]Richard Frank Consulting , Washington, DC, USA
[35
]Oregon Health and Science University , Portland, Oregon, USA
[36
]Baylor College of Medicine , Houston, Texas, USA
[37
]University of Alabama , Birmingham, Alabama, USA
[38
]Mount Sinai School of Medicine , New York City, New York, USA
[39
]Rush University Medical Center , Chicago, Illinois, USA
[40
]Wien Center , Miami, Florida, USA
[41
]New York University , New York City, New York, USA
[42
]Duke University Medical Center , Durham, North Carolina, USA
[43
]University of Kentucky , Lexington, Kentucky, USA
[44
]University of Rochester Medical Center , Rochester, New York, USA
[45
]University of Texas Southwestern Medical School , Dallas, Texas, USA
[46
]Emory University , Atlanta, Georgia, USA
[47
]University of Kansas, Medical Center , Kansas City, Kansas, USA
[48
]Mayo Clinic , Jacksonville, Florida, USA
[49
]Yale University School of Medicine , New Haven, Connecticut, USA
[50
]McGill University/Montreal-Jewish General Hospital , Montreal, Quebec, Canada
[51
]Sunnybrook Health Sciences , Toronto, Ontario, Canada
[52
]U.B.C. Clinic for AD & Related Disorders , Vancouver, British Columbia, Canada
[53
]Cognitive Neurology–St Joseph's , London, Ontario, Canada
[54
]Cleveland Clinic Lou Ruvo Center for Brain Health , Las Vegas, Nevada, USA
[55
]St Joseph's Health Care , London, Ontario, Canada
[56
]Premiere Research Institute, Palm Beach Neurology , Miami, Florida, USA
[57
]Georgetown University Medical Center , Washington, DC, USA
[58
]Banner Sun Health Research Institute , Sun City, Arizona, USA
[59
]Boston University , Boston, Massachusetts, USA
[60
]Howard University , Washington, DC, USA
[61
]Case Western Reserve University , Cleveland, Ohio, USA
[62
]Neurological Care of CNY , Liverpool, New York, USA
[63
]Parkwood Hospital , London, Ontario, USA
[64
]University of Wisconsin , Madison, Wisconsin, USA
[65
]Dent Neurologic Institute , Amherst, New York, USA
[66
]Ohio State University , Columbus, Ohio, USA
[67
]Albany Medical College , Albany, New York, USA
[68
]Hartford Hospital, Olin Neuropsychiatry Research Center , Hartford, Connecticut, USA
[69
]Dartmouth-Hitchcock Medical Center , Lebanon, New Hampshire, USA
[70
]Wake Forest University Health Sciences , Winston-Salem, North Carolina, USA
[71
]Rhode Island Hospital , Providence, Rhode Island, USA
[72
]Butler Hospital , Providence, Rhode Island, USA
[73
]Medical University South Carolina , Charleston, South Carolina, USA
[74
]Nathan Kline Institute , Orangeburg, New York, USA
[75
]University of Iowa College of Medicine , Iowa City, Iowa, USA
[76
]University of South Florida: USF Health Byrd Alzheimer's Institute , Tampa, Florida, USA
[77
]Department of Defense , Arlington, Virginia, USA
[78
]Stanford University , Stanford, California, USA
Late-onset Alzheimer's disease (LOAD) is a complex multi-factorial disorder. Here,
the authors perform a data-driven analysis of LOAD progression, including multimodal
brain imaging, plasma and CSF biomarkers, and find vascular dysfunction is among the
earliest and strongest altered events.
