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      • Record: found
      • Abstract: found
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      Erratum to: Expression profiling of white sponge nevus by RNA sequencing revealed pathological pathways

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          Abstract

          Erratum After publication of [1] the authors realised that the original publication had two descriptive errors when referring to diseases. “periodontal” was written rather than “mucous membrane” in the article on page 1, lines 12 and 25. “periodontal disease” was written rather than “mucous membrane hyperkeratosis” in the article on page 2, lines 72 and 73. The correct spelling of these is included in this erratum.

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          Expression profiling of white sponge nevus by RNA sequencing revealed pathological pathways

          Wenping Cai, Beizhan Jiang, Tienan Feng … (2015)
          Background White sponge nevus (WSN) is a rare periodontal hereditary disease. To date, almost all WSN studies have focused on case reports or mutation reports. Thus, the mechanism behind WSN is still unclear. We investigated the pathogenesis of WSN using expression profiling. Methods Sequence analysis of samples from a WSN Chinese family revealed a mutation (332 T > C) in the KRT13 gene that resulted in the amino acid change Leu111Pro. The pathological pathway behind the WSN expression profile was investigated by RNA sequencing (RNA-seq). Results Construction of a heatmap revealed 24 activated genes and 57 reduced genes in the WSN patients. The ribosome structure was damaged in the WSN patients. Moreover, the translation rate was limited in the WSN patients, whereas ubiquitin-mediated proteolysis was enhanced. Conclusions Our results suggest that the abnormal degradation of the KRT13 protein in WSN patients may be associated with keratin 7 (KRT7) and an abnormal ubiquitination process. Electronic supplementary material The online version of this article (doi:10.1186/s13023-015-0285-y) contains supplementary material, which is available to authorized users.
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            Author and article information

            Contributors
            Wenping Cai: wenpingcai@126.com
            Beizhan Jiang: jiangbeizhan@tongji.edu.cn
            Tienan Feng: tienan_feng@126.com
            Jinfeng Xue: xuejinfeng@sklmg.edu.cn
            Jianhua Yang: jianhuay@bcm.edu
            Zhenghu Chen: chenzhenghu111@163.com
            Junjun Liu: ljj19931202@163.com
            Rongbin Wei: ljj19931202@163.com
            Shouliang Zhao: slzhao@tongji.edu.cn
            Xiaoping Wang: wxp990@hotmail.com
            Shangfeng Liu: shangfengliufudan@163.com
            Journal
            Journal ID (nlm-ta): Orphanet J Rare Dis
            Journal ID (iso-abbrev): Orphanet J Rare Dis
            Title: Orphanet Journal of Rare Diseases
            Publisher: BioMed Central (London )
            ISSN (Electronic): 1750-1172
            Publication date (Electronic): 23 September 2015
            Publication date PMC-release: 23 September 2015
            Publication date Collection: 2015
            Volume: 10
            Electronic Location Identifier: 119
            Affiliations
            [ ]Department of Stomatology, Huashan Hospital, Fudan University, Shanghai, 200040 P. R. China
            [ ]Laboratory of Oral Biomedical Science and Translational Medicine, School of Stomatology, Tongji University, Shanghai, 200072 P. R. China
            [ ]School of Life sciences and Technology, Tongji University, Shanghai, 200065 P. R. China
            [ ]State Key Laboratory of Medical Genetics, Central South University, Changsha, 410078 P. R. China
            [ ]Department of Ophthalmology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China
            Article
            Publisher ID: 308
            DOI: 10.1186/s13023-015-0308-8
            PMC ID: 4581163
            SO-VID: b77c04fe-9dab-4608-a76e-72ac89f245b2
            Copyright © © Cai et al. 2015
            License:

            Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

            History
            Date received : 17 July 2015
            Date accepted : 17 July 2015
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            Subject: Erratum
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            ScienceOpen disciplines: Infectious disease & Microbiology
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            ScienceOpen disciplines: Infectious disease & Microbiology

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