Oxygen homeostasis.

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Abstract

Metazoan life is dependent upon the utilization of O(2) for essential metabolic processes and oxygen homeostasis is an organizing principle for understanding metazoan evolution, ontology, physiology, and pathology. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is expressed by all metazoan species and functions as a master regulator of oxygen homeostasis. Recent studies have elucidated complex mechanisms by which HIF-1 activity is regulated and by which HIF-1 regulates gene expression, with profound consequences for prenatal development, postnatal physiology, and disease pathogenesis.

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Journal

Journal ID (iso-abbrev): Wiley Interdiscip Rev Syst Biol Med

Title: Wiley interdisciplinary reviews. Systems biology and medicine

Publisher: Wiley

ISSN (Electronic): 1939-005X

ISSN (Print): 1939-005X

Publication date (Electronic): September 14 2010

Volume: 2

Issue: 3

Affiliations

[1 ] Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA.

[2 ] Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, and Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA.

[3 ] McKusick-Nathans Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, Baltimore, MA 21205, USA.

Article

DOI: 10.1002/wsbm.69

PubMed ID: 20836033

SO-VID: b7081217-887b-4bf5-9fb0-9610f8112abd

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