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Clinical effect of point mutations in myelodysplastic syndromes.

Author(s): Rafael Bejar, Kristen Stevenson, Omar Abdel-Wahab, Naomi Galili, Björn Nilsson, Guillermo Garcia-Manero, Hagop Kantarjian, Azra Raza, Ross L Levine, Donna Neuberg, Benjamin L Ebert

Publication date: 2011-06-30

Journal: The New England journal of medicine

Publisher: Massachusetts Medical Society

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Abstract

Myelodysplastic syndromes are clinically heterogeneous disorders characterized by clonal hematopoiesis, impaired differentiation, peripheral-blood cytopenias, and a risk of progression to acute myeloid leukemia. Somatic mutations may influence the clinical phenotype but are not included in current prognostic scoring systems.

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PubMed ID:: 21714648

PMC ID:: 3159042

DOI:: 10.1056/NEJMoa1013343

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