Subchondral chitosan/blood implant-guided bone plate resorption and woven bone repair is coupled to hyaline cartilage regeneration from microdrill holes in aged rabbit knees.

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Abstract

Little is known of how to routinely elicit hyaline cartilage repair tissue in middle-aged patients. We tested the hypothesis that in skeletally aged rabbit knees, microdrill holes can be stimulated to remodel the bone plate and induce a more integrated, voluminous and hyaline cartilage repair tissue when treated by subchondral chitosan/blood implants.

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Journal

Journal ID (iso-abbrev): Osteoarthr. Cartil.

Title: Osteoarthritis and cartilage

ISSN (Electronic): 1522-9653

ISSN (Print): 1063-4584

Publication date (Electronic): Feb 2014

Volume: 22

Issue: 2

Affiliations

[1 ] Department of Chemical Engineering, École Polytechnique, C.P. 6079 succ. Centre-Ville, Montréal, QC, Canada H3C 3A7. Electronic address: jessica.guzman-morales@polymtl.ca.

[2 ] Institute of Biomedical Engineering, École Polytechnique, C.P. 6079 succ. Centre-Ville, Montréal, QC, Canada H3C 3A7. Electronic address: charles-hubert.lafantaisie-favreau@polymtl.ca.

[3 ] Department of Chemical Engineering, École Polytechnique, C.P. 6079 succ. Centre-Ville, Montréal, QC, Canada H3C 3A7. Electronic address: gaoping.chen@polymtl.ca.

[4 ] Department of Chemical Engineering, École Polytechnique, C.P. 6079 succ. Centre-Ville, Montréal, QC, Canada H3C 3A7; Institute of Biomedical Engineering, École Polytechnique, C.P. 6079 succ. Centre-Ville, Montréal, QC, Canada H3C 3A7; Groupe de Recherche en Sciences et Technologies Biomédicales (GRSTB), École Polytechnique, C.P. 6079 succ. Centre-Ville, Montréal, QC, Canada H3C 3A7. Electronic address: caroline.hoemann@polymtl.ca.

Article

Publisher Item ID: S1063-4584(13)01044-3

DOI: 10.1016/j.joca.2013.12.011

PubMed ID: 24361795

SO-VID: b2967f78-b0fa-427b-9f6d-434adc6a9018

History

Keywords: Bone marrow stimulation,Bone remodeling,Cartilage repair,Chitosan particles,Implant,Subchondral bone plate

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Keywords: Bone marrow stimulation, Bone remodeling, Cartilage repair, Chitosan particles, Implant, Subchondral bone plate

Subchondral chitosan/blood implant-guided bone plate resorption and woven bone repair is coupled to hyaline cartilage regeneration from microdrill holes in aged rabbit knees.

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