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Abstract
<p class="first" id="P1">Domoic acid (DA) is a neurotoxin that is naturally produced
by phytoplankton and accumulates
in seafood during harmful algal blooms. As the prevalence of DA increases in the marine
environment, there is a critical need to identify seafood consumers at risk of DA
poisoning. DA exposure was estimated in recreational razor clam (
<i>Siliqua patula</i>) harvesters to determine if exposures above current regulatory
guidelines occur and/or
if harvesters are chronically exposed to low levels of DA. Human consumption rates
of razor clams were determined by distributing 1,523 surveys to recreational razor
clam harvesters in spring 2015 and winter 2016, in Washington, USA. These consumption
rate data were combined with DA measurements in razor clams, collected by a state
monitoring program, to estimate human DA exposure. Approximately seven percent of
total acute exposures calculated (including the same individuals at different times)
exceeded the current regulatory reference dose (0.075 mg DA· kg bodyweight
<sup>−1</sup> · d
<sup>−1</sup>) due to higher than previously reported consumption rates, lower body
weights, and/or
by consumption of clams at the upper range of legal DA levels (maximum 20 mg · kg
<sup>−1</sup> wet weight for whole tissue). Three percent of survey respondents were
potentially
at risk of chronic DA exposure by consuming a minimum of 15 clams per month for at
12 consecutive months. These insights into DA consumption will provide an additional
tool for razor clam fishery management.
</p>