Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma.

Biagini Myers, Jocelyn M.; Martin, Lisa J.; Kovacic, Melinda Butsch; Mersha, Tesfaye B; HE, Hua; Pilipenko, Valentina; Lindsey, Mark A; Ericksen, Mark B.; Bernstein, David I; LeMasters, Grace K; Lockey, James E.; Khurana Hershey, Gurjit K.

doi:10.1016/j.jaci.2014.03.037

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Epistasis between serine protease inhibitor Kazal-type 5 (SPINK5) and thymic stromal lymphopoietin (TSLP) genes contributes to childhood asthma.

Author(s): Jocelyn M. Biagini Myers, Lisa Martin, Melinda Kovacic, Tesfaye Mersha, Hua HE, Valentina Pilipenko, Mark Lindsey, Mark B. Ericksen, David I Bernstein, Grace K LeMasters, James E. Lockey, Gurjit K. Khurana Hershey

Publication date: 2014-10-01

Journal: The Journal of Allergy and Clinical Immunology

Publisher: Elsevier BV

Keywords: Childhood asthma, skin-related genes, epistasis, genetic association

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Abstract

Epithelial genes have previously been associated with asthma but only explain a small fraction of heritability. In part, this might be due to epistasis, which is often not considered.