A convenient method for synthesis of terpyridines via a cooperative vinylogous anomeric based oxidation†

Abstract

The presented study is the first report of the synthesis of terpyridines in the presence of a nanomagnetic catalyst instead of harmful reagents. Herein, Fe ₃O ₄@O ₂PO ₂(CH ₂) ₂NH ₃ ⁺CF ₃CO ₂ ⁻ as a retrievable nanocatalyst with magnetic properties was applied for the multi-component reaction between acetylpyridine derivatives (2 or 3 or 4-isomer), aryl aldehydes and ammonium acetate under conventional heating conditions in the absence of any solvent. The derived terpyridines were obtained with acceptable yields and brief reaction times via a cooperative vinylogous anomeric based oxidation route. Fe ₃O ₄@O ₂PO ₂(CH ₂) ₂NH ₃ ⁺CF ₃CO ₂ ⁻ showed a high capability for recovery and reuse in the mentioned reaction.

Abstract

Fe ₃O ₄@O ₂PO ₂(CH ₂) ₂NH ₃ ⁺CF ₃CO ₂ ⁻ as a retrievable nanocatalyst with magnetic properties was applied for the one pot preparation of terpyridines with good yields and short reaction times via a cooperative vinylogous anomeric based oxidation mechanism.