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      MicroRNAs in prostate cancer: Functional role as biomarkers.

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          Abstract

          MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Cancer Lett.
          Title: Cancer letters
          Publisher: Elsevier BV
          ISSN (Electronic): 1872-7980
          ISSN (Print): 0304-3835
          Publication date (Electronic): October 28 2017
          Volume: 407
          Affiliations
          [1 ] Department of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA; The Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA; Department of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, USA.
          [2 ] Center of Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 44115, USA; Department of Biological Sciences, Cleveland State University, Cleveland, OH, 44115, USA.
          [3 ] Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.
          [4 ] Department of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA; The Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA; Department of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, USA; Department of Nutrition, Case Western Reserve University, Cleveland, OH, 44106, USA; Division of General Medical Sciences, Case Comprehensive Cancer Center, Cleveland, OH, 44106, USA. Electronic address: sanjay.gupta@case.edu.
          Article
          Publisher Item ID: S0304-3835(17)30488-3
          DOI: 10.1016/j.canlet.2017.08.011
          PubMed ID: 28823964
          SO-VID: 92156c7e-9f35-4644-a926-7c9bdd0694b4
          History

          Keywords: Androgen receptor,Biomarkers,Castrate-resistant prostate cancer,Non-coding RNA,Oncomirs,Tumor suppressor
          Data availability:
          Keywords: Androgen receptor, Biomarkers, Castrate-resistant prostate cancer, Non-coding RNA, Oncomirs, Tumor suppressor

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