If a quark-gluon plasma is formed in relativistic heavy-ion collisions, there may or may not be a mixed phase of quarks, gluons and hadronic clusters when the critical temperature is reached in the expansion of the fireball. If there is a temperature gradient in the fireball, the hadronic clusters, embedded in the heat bath of quarks and gluons, are subjected to a thermophoretic force. It is shown that even for small temperature gradients and short lifetimes of the mixed phase, thermophoresis would lead to a flow essentially stronger than the observed one. The absence of this strong flow provides support for a rapid or sudden hadronization mechanism without a mixed phase.