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CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice.
Dayea Kim
1 ,
Jaeyoon Kim ,
Jong Hyuk Yoon ,
Jaewang Ghim ,
Kyungmoo Yea ,
Parkyong Song ,
Soyeon Park ,
Areum Lee ,
Chun-Pyo Hong ,
Min Seong Jang ,
Yonghoon Kwon ,
Sehoon Park ,
Myoung Ho Jang ,
Per-Olof Berggren ,
Pann-Ghill Suh ,
Sung Ho Ryu
Jul 2014
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Abstract
Obesity-induced inflammation is initiated by the recruitment of macrophages into adipose tissue. The recruited macrophages, called adipose tissue macrophages, secrete several proinflammatory cytokines that cause low-grade systemic inflammation and insulin resistance. The aim of this study was to find macrophage-recruiting factors that are thought to provide a crucial connection between obesity and insulin resistance.