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Probiotic‐derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation
Mengwei Jiang ,
Fengyuan Li ,
Yunhuan Liu ,
Zelin Gu ,
Lihua Zhang ,
Jiyeon Lee ,
Liqing He ,
Vatsalya Vatsalya ,
Huang‐Ge Zhang ,
Zhongbin Deng ,
Xiang Zhang ,
Shao‐Yu Chen ,
Grace L. Guo ,
Shirish Barve ,
Craig J. McClain ,
Wenke Feng
July 7 2022
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Abstract
Intestinal farnesoid X receptor (FXR) plays a critical role in alcohol-associated
liver disease (ALD). We aimed to investigate whether alcohol-induced dysbiosis increased
intestinal microRNA194 (miR194) that suppressed Fxr transcription and whether Lactobacillus
rhamnosus GG-derived exosome-like nanoparticles (LDNPs) protected against ALD through
regulation of intestinal miR194-FXR signaling in mice.